Skip to Content
Merck
CN

E4642

(±)-Epinephrine hydrochloride

≥98% (TLC), powder, adrenergic receptor agonist

Synonym(s):

(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C9H13NO3 · HCl
CAS Number:
329-63-5
Molecular Weight:
219.67
NACRES:
NA.77
PubChem Substance ID:
24278422
UNSPSC Code:
12352200
EC Number:
206-346-0
MDL number:
MFCD00050562

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

(±)-Epinephrine hydrochloride,

InChI key

ATADHKWKHYVBTJ-UHFFFAOYSA-N

InChI

1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H

SMILES string

OC(CNC)C1=CC=C(O)C(O)=C1.Cl

solubility

H2O: 50 mg/mL

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

(±)-Epinephrine hydrochloride has been used:
  • in the induction of renalase expression in Human renal proximal tubular epithelial cells
  • in the infusion studies to test its effect on heart rate and eye temperature measurements in bull
  • as a medium supplement for the stimulation of endothelial progenitor cells

Biochem/physiol Actions

Adrenergic receptor agonist.
Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility. It is used in the treatment of acute anaphylaxis. Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.

General description

Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system. It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors. Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.

Other Notes

The ratio of +/- adrenaline is not determined.

wgk

WGK 3

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCX8585
MKCX4598
MKCW8265
MKCV8354
MKCT3686

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT
Martin JL, et al.
Structure, 9(10), 977-985 (2001)
Advantages and disadvantages of adrenaline in regional anaesthesia
Niemi G
Best Practice & Research. Clinical Anaesthesiology, 19(2), 229-245 (2005)
Sympathetic predominance is associated with impaired endothelial progenitor cells and tunneling nanotubes in controlled-hypertensive patients
de Cavanagh EAMV, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 307, H207?H215-H207?H215 (2014)
M Stewart et al.
Journal of dairy science, 93(11), 5252-5257 (2010-10-23)
Changes in autonomic nervous system (ANS) activity are one of the first phases of a stress response, but they are rarely used to assess the welfare of farm animals. Eye temperature measured using infrared thermography (IRT) is proposed as an
Adrenaline, cardiac arrest, and evidence based medicine.
Rainer TH and Robertson CE
Emergency Medicine Journal : EMJ, 13(4), 234-237 (1996)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service