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F9552

Formoterol fumarate dihydrate

Name: Formoterol fumarate dihydrate
Brand: SIGMA

>98% (HPLC), solid, β₂-Adrenoreceptor agonist.

Synonym(s):

(R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate, Formoterol hemifumarate salt monohydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₄N₂O₄ · 0.5C₄H₄O₄ · H₂O

CAS Number:

183814-30-4

Molecular Weight:

420.46

UNSPSC Code:

12352200

PubChem Substance ID:

24278448

NACRES:

NA.77

MDL number:

MFCD11045919

Assay:

>98% (HPLC)

Form:

solid

Quality level:

100

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Product Name

Formoterol fumarate dihydrate, >98% (HPLC)

Quality Level

100

assay

>98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: soluble 20 mg/mL, H₂O: insoluble

originator

Novartis

SMILES string

O.O.OC(=O)\C=C\C(O)=O.COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1.COc3ccc(C[C@H](C)NC[C@@H](O)c4ccc(O)c(NC=O)c4)cc3

InChI

1S/2C19H24N2O4.C4H4O4.2H2O/c2*1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8;;/h2*3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8);2*1H2/b;;2-1+;;/t2*13-,19+;;;/m00.../s1

InChI key

RATSWNOMCHFQGJ-TUYNVFRMSA-N

Gene Information

human ... ADRB2(154)

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Related Categories

Bioactive Small Molecule Agonists

Bioactive Small Molecules

Application

Formoterol fumarate dihydrate has been used:

as β₂-adrenergic agonist, to determine whether β₂-adrenergic receptor signaling was sufficient to induce up-regulation of select gene transcripts
as a β₂-adrenergic receptor agonist and a long term bronchodilator
as β₂-adrenergic receptor (β₂AR) agonist to recover renal function in ischemia-reperfusion injury (IRI) in mice

Biochem/physiol Actions

Formoterol fumarate dihydrate can be used along with budesonide to treat asthma.

β₂-Adrenoreceptor agonist.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H332,H361d,H370,H373,H412

pcodes

P202 - P260 - P264 - P273 - P304 + P340 + P312 - P308 + P311

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Repr. 2 - STOT RE 2 - STOT SE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000510074

0000487768

0000487770

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Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma

Patel K R, et al.

Faseb Journal, 31(10), 4335-4346 (2017)

beta-Adrenergic-stimulated macrophages: comprehensive localization in the M1-M2 spectrum

Lamkin D M, et al.

Brain, behavior, and immunity, 57(7), 338-346 (2016)

Proximal Tubule beta2 Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function After Ischemia-Reperfusion Injury.

Cameron R B, et al.

Journal of Pharmacology and Experimental Therapeutics, 31(10), 4335-4346 (2019)

Budesonide+ formoterol fumarate dihydrate for the treatment of asthma

Wolthers O D

Expert Opinion on Pharmacotherapy, 17(7), 1023-1030 (2016)

Proximal Tubule β2-Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function after Ischemia-Reperfusion Injury.

Robert B Cameron et al.

The Journal of pharmacology and experimental therapeutics, 369(1), 173-180 (2019-02-03)

Acute kidney injury (AKI) is the rapid loss of renal function after an insult, and renal proximal tubule cells (RPTCs) are central to the pathogenesis of AKI. The β2-adrenergic receptor (β2AR) agonist formoterol accelerates the recovery of renal function in

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Global Trade Item Number

SKU	GTIN
F9552-50MG	04061833621882
F9552-10MG	04061833621875

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