G019
Muscimol hydrobromide
≥98% (HPLC), GABAA receptor agonist, solid
Synonym(s):
5-Aminomethyl-3-hydroxyisoxazole hydrobromide
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About This Item
Empirical Formula (Hill Notation):
C4H6N2O2 · HBr
CAS Number:
Molecular Weight:
195.01
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Product Name
Muscimol hydrobromide, ≥98% (HPLC), solid
Assay
≥98% (HPLC)
form
solid
color
off-white to tan
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
SMILES string
Br[H].NCc1cc(O)no1
InChI
1S/C4H6N2O2.BrH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H
InChI key
OPZOJWHOZRKYQX-UHFFFAOYSA-N
Gene Information
Biochem/physiol Actions
Muscimol hydrobromide is a GABAA receptor agonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Max F K Happel et al.
PloS one, 12(1), e0169461-e0169461 (2017-01-04)
Robust perception of auditory objects over a large range of sound intensities is a fundamental feature of the auditory system. However, firing characteristics of single neurons across the entire auditory system, like the frequency tuning, can change significantly with stimulus
Daniel H O'Connor et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(5), 1947-1967 (2010-02-05)
Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as the mouse. In head-fixed primates, the combination of precise stimulus control, monitoring of motor output, and physiological recordings over
Elina A K Jacobs et al.
Current biology : CB, 30(24), 4944-4955 (2020-10-24)
In many behavioral tasks, cortex enters a desynchronized state where low-frequency fluctuations in population activity are suppressed. The precise behavioral correlates of desynchronization and its global organization are unclear. One hypothesis holds that desynchronization enhances stimulus coding in the relevant
Suriya Subramanian et al.
Brain structure & function, 223(6), 2907-2924 (2018-04-28)
The lateral preoptic area (LPO) and ventral pallidum (VP) are structurally and functionally distinct territories in the subcommissural basal forebrain. It was recently shown that unilateral infusion of the GABAA receptor antagonist, bicuculline, into the LPO strongly invigorates exploratory locomotion
Mohammed Z Ariffin et al.
Frontiers in neuroanatomy, 11, 79-79 (2017-10-03)
Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and cingulate cortex (Cg). In the present study, we
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