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Merck
CN

H5534

trans-4-Hydroxy-L-proline

≥98.5%, suitable for cell culture, BioReagent

Synonym(s):

4-Hydroxyproline, Hydroxyproline, (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp

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About This Item

Empirical Formula (Hill Notation):
C5H9NO3
CAS Number:
Molecular Weight:
131.13
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-091-9
MDL number:
Beilstein/REAXYS Number:
81441
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Product Name

trans-4-Hydroxy-L-proline, BioReagent, suitable for cell culture, ≥98.5%

product line

BioReagent

Quality Level

assay

≥98.5%

form

crystalline

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless

mp

273 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

application(s)

peptide synthesis

SMILES string

O[C@H]1CN[C@@H](C1)C(O)=O

InChI

1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

InChI key

PMMYEEVYMWASQN-DMTCNVIQSA-N

Application


  • Cysteine Radical and Glutamate Collaboratively Enable C-H Bond Activation and C-N Bond Cleavage in a Glycyl Radical Enzyme HplG.: This research showcases the application of trans-4-hydroxy-L-proline in studying enzymatic reactions that involve C-H bond activation and C-N bond cleavage, providing insights into the mechanisms of enzymatic control and specificity which are essential for the development of novel biochemical processes (Deng and Liao, 2024).

  • Study on flavor quality formation in green and yellow tea processing by means of UPLC-MS approach.: Utilizing trans-4-hydroxy-L-proline, this study enhances the understanding of flavor biochemistry in tea processing, offering significant insights into the food chemistry sector and influencing future product development strategies (Sun et al., 2024).


Other Notes

Natural constituent of animal structural proteins such as collagen and elastin.


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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Proline and hydroxyproline metabolism: implications for animal and human nutrition
Guoyao Wu
Amino Acids, 40{4}, 1053-1063 (2011)
Lodish H
Molecular Cell Biology (2000)
Biochemical Markers of Bone Turnover Part I: Biochemistry and Variability
Biochemical Markers of Bone Turnover Part I: Markus J Markus J Seibel
The Clinical Biochemist. Reviews / Australian Association of Clinical Biochemists, 26(4), 97-122 (2005)



Global Trade Item Number

SKUGTIN
H5534-100G04061834402695
H5534-10MG04061833799567
H5534-25G04061833799574
H5534-1KG04061834402701