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H6034

L-Histidine

Name: <SC>L</SC>-Histidine
Brand: SIGMA

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, USP testing specifications

Synonym(s):

(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773

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About This Item

Empirical Formula (Hill Notation):

C₆H₉N₃O₂

CAS Number:

71-00-1

Molecular Weight:

155.15

NACRES:

NA.26

PubChem Substance ID:

24895728

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-745-3

MDL number:

MFCD00064315

Beilstein/REAXYS Number:

84088

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Product Name

L-Histidine, suitable for cell culture, meets EP, USP testing specifications, from non-animal source

biological source

non-animal source

Quality Level

300

agency

meets EP testing specifications, meets USP testing specifications

assay

98.5-101.0%

form

powder

optical activity

[α]20/D 12.0 to 12.8 °, c = 11 in 6 M HCl, [α]25/D 12.6 to 14.0 °, c = 11 in 6 M HCl

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white to off-white

mp

282 °C (dec.) (lit.)

solubility

H₂O: 50 mg/mL

cation traces

As: ≤1 ppm, Fe: ≤10 ppm, NH₄⁺: <0.02%

application(s)

advanced drug delivery
peptide synthesis
pharmaceutical (small molecule)

functional group

(Imidazole), amine, carboxylic acid

storage temp.

room temp

SMILES string

N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

Gene Information

human ... CA1(759), CA2(760)

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Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

Biochemicals

Cell Culture Supplements & Reagents

Building Blocks, Resins, and Coupling Reagents for GLP-1 Synthesis

Amino Acids – Building Blocks of Life Science

General description

L-Histidine is a proteinogenic amino acid and an essential amino acid required for histamine production. This positively charged amino acid is vital for growth, tissue repair, myelin sheath maintenance, and histamine synthesis. Histamine plays critical roles in immunity, gastric secretion, and more. L-Histidine is essential for blood cell production and tissue protection against radiation and heavy metals. L-Histidine plays a role as a metabolite and also acts as a cofactor in enzyme protection during protein synthesis. It is an L-enantiomer of histidine and is necessary for histamine synthesis and human development. L-Histidine finds applications in cell culture, metabolomics and biochemical research.

Application

L-histidine has been used as a component in agar plates containing 5-fluorocytosine (5-FC) for the selection of yeast transformants. It has also been used as a component of adult mouse keratinocyte growth medium.

Biochem/physiol Actions

L-Histidine is an essential amino acid that binds to metal ions and may aid in the transport of copper. Histidine is widely present at the active sites of enzymes. It also has a role in binding of heme groups, macromolecules and phosphate groups in the binding sites of proteins.

Precursor of histamine by action of histidine decarboxylase.

Features and Benefits

Can be used in Metabolomics and Biochemical research
High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A method for high-throughput production of sequence-verified DNA libraries and strain collections

Roger L. Lundblad

Justin D

Molecular Systems Biology (2017)

Catherine Collin

Advances in Neurochemistry (2005)

Eric R. Braverman

The Healing Nutrients Within: Facts, Findings, and New Research on Amino Acids (2003)

Serial Cultivation of Primary Adult Murine Keratinocytes

Richard P. Redvers and Pritinder Kaur

Methods in Molecular Biology (2005)

Ruminal bacterial community shifts in grain-, sugar-, and histidine-challenged dairy heifers.

H M Golder et al.

Journal of dairy science, 97(8), 5131-5150 (2014-06-03)

Ruminal bacterial community composition (BCC) and its associations with ruminal fermentation measures were studied in dairy heifers challenged with combinations of grain, fructose, and histidine in a partial factorial study. Holstein-Friesian heifers (n=30) were randomly allocated to 5 triticale grain-based

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Global Trade Item Number

SKU	GTIN
H6034-25G	04061835545599
H6034-100G	04061835521869
H6034-10MG	04061833486818
H6034-1KG	04061833800249

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