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Merck
CN

H6903

HEPBS

≥99% (titration), powder, pH 7.6-9.0

Synonym(s):

PBS, phosphate buffered saline, N-(2-Hydroxyethyl)piperazine-N′-(4-butanesulfonic acid)

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About This Item

Empirical Formula (Hill Notation):
C10H22N2O4S
CAS Number:
161308-36-7
Molecular Weight:
266.36
UNSPSC Code:
12161700
NACRES:
NA.25
MDL number:
MFCD00677124

Key Documents

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Product Name

HEPBS, ≥99% (titration)

SMILES string

[S](=O)(=O)(O)CCCCN1CCN(CC1)CCO

InChI

1S/C10H22N2O4S/c13-9-8-12-6-4-11(5-7-12)3-1-2-10-17(14,15)16/h13H,1-10H2,(H,14,15,16)

InChI key

LOJNFONOHINEFI-UHFFFAOYSA-N

assay

≥99% (titration)

form

powder

pH

7.6-9.0

useful pH range

7.6-9.0

pKa (25 °C)

8.3

pKa 

8.3

solubility

water: 0.5 g/mL, clear to slightly hazy, colorless to faintly yellow

application(s)

diagnostic assay manufacturing

Quality Level

200

Related Categories

General description

HEPBS/N-(2-Hydroxyethyl)piperazine-N′-(4-butanesulfonic acid) is mainly used in buffer preparations.

Other Notes

Homolog of HEPES and EPPS with higher pKa and similar utility in biological systems.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000513852
0000513852
0000447831
0000447831
0000426665

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Template-Directed Synthesis in 3?-and 5?-Direction with Reversible Termination
Kaiser A, et al.
Angewandte Chemie (International Edition in English), 51(33), 8299-8303 (2012)
T Thiel et al.
Journal of biochemical and biophysical methods, 37(3), 117-129 (1998-12-31)
Four new zwitterionic butanesulfonic acid buffers that are structurally related to four families of Good buffers were evaluated for use in biological systems. These buffers, with pKa values from 7.6 to 10.7, were compared with a variety of other buffers
Michael Bachmann et al.
Journal of cell science, 133(9) (2020-03-21)
αVβ3 integrin can bind to multiple extracellular matrix proteins, including vitronectin (Vn) and fibronectin (Fn), which are often presented to cells in culture as homogenous substrates. However, in tissues, cells experience highly complex and changing environments. To better understand integrin

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