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Merck
CN

H6903

HEPBS

≥99% (titration), powder, pH 7.6-9.0

Synonym(s):

PBS, phosphate buffered saline, N-(2-Hydroxyethyl)piperazine-N′-(4-butanesulfonic acid)

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About This Item

Empirical Formula (Hill Notation):
C10H22N2O4S
CAS Number:
161308-36-7
Molecular Weight:
266.36
MDL number:
MFCD00677124
UNSPSC Code:
12161700
NACRES:
NA.25

Key Documents

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Product Name

HEPBS, ≥99% (titration)

Quality Level

200

Assay

≥99% (titration)

form

powder

pH

7.6-9.0

useful pH range

7.6-9.0

pKa (25 °C)

8.3

pKa 

8.3

solubility

water: 0.5 g/mL, clear to slightly hazy, colorless to faintly yellow

application(s)

diagnostic assay manufacturing

SMILES string

[S](=O)(=O)(O)CCCCN1CCN(CC1)CCO

InChI

1S/C10H22N2O4S/c13-9-8-12-6-4-11(5-7-12)3-1-2-10-17(14,15)16/h13H,1-10H2,(H,14,15,16)

InChI key

LOJNFONOHINEFI-UHFFFAOYSA-N

Related Categories

General description

HEPBS/N-(2-Hydroxyethyl)piperazine-N′-(4-butanesulfonic acid) is mainly used in buffer preparations.

Other Notes

Homolog of HEPES and EPPS with higher pKa and similar utility in biological systems.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000513852
0000513852
0000447831
0000447831
0000426665

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Template-Directed Synthesis in 3?-and 5?-Direction with Reversible Termination
Kaiser A, et al.
Angewandte Chemie (International Edition in English), 51(33), 8299-8303 (2012)
T Thiel et al.
Journal of biochemical and biophysical methods, 37(3), 117-129 (1998-12-31)
Four new zwitterionic butanesulfonic acid buffers that are structurally related to four families of Good buffers were evaluated for use in biological systems. These buffers, with pKa values from 7.6 to 10.7, were compared with a variety of other buffers
Michael Bachmann et al.
Journal of cell science, 133(9) (2020-03-21)
αVβ3 integrin can bind to multiple extracellular matrix proteins, including vitronectin (Vn) and fibronectin (Fn), which are often presented to cells in culture as homogenous substrates. However, in tissues, cells experience highly complex and changing environments. To better understand integrin

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