I1142
Monoclonal Anti-Interferon-γ antibody produced in rat
clone 37895, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-IFN-γ
Product Name
Monoclonal Anti-Interferon-γ antibody produced in rat, clone 37895, purified immunoglobulin, lyophilized powder
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
37895, monoclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
flow cytometry: suitable
neutralization: suitable
western blot: suitable
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Ifng(15978)
Related Categories
General description
Interferon-γ (IFN-γ) belongs to Type II class of interferons and is produced by T helper cells (specifically, Th1 cells), natural killer (NK) and natural killer T (NKT) cells and cytotoxic T cells (TC cells) . It has various biological functions including antiviral activity like inhibition of cell or tumor growth, act as a potent modulator of immune responses and modifies cellular processes as well as stimulates the differentiation of B cells into immunoglobulin-producing cells. Monoclonal Anti-Interferon-γ antibody can be used in immunoblotting. Rat anti-Interferon-γ antibody has shown no cross-reactivity for recombinant human IFN-γ or recombinant rat IFN-γ.
Immunogen
recombinant mouse IFN-γ.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline and 5% trehalose.
Preparation Note
Purified from cell culture supernatant using protein G.
Application
Monoclonal Anti-Interferon-γ antibody can be used in neutralization and indirect ELISA.
Biochem/physiol Actions
The antibody does not cross-react with recombinat human IFN-γ or recombinant rat IFN-γ.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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I Gresser et al.
Proceedings of the National Academy of Sciences of the United States of America, 66(4), 1052-1058 (1970-08-01)
Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells in stationary suspension cultures. The degree of inhibition was found to correlate with the antiviral titer of the interferon preparations. The factor(s) responsible for inhibition of L 1210
P B Fisher et al.
Pharmacology & therapeutics, 27(2), 143-166 (1985-01-01)
As described in this review, both partially purified and recombinant interferons are potent modulators of differentiation in diverse cell culture systems (Table 2). Depending on the target cell, interferon exerts either an inhibitory or an inductive effect on cell differentiation.
J Vilcek et al.
Journal of immunology (Baltimore, Md. : 1950), 135(3), 1851-1856 (1985-09-01)
Interferon (IFN)-gamma production, stimulated by the addition of exogenous interleukin (IL) 2, T cell mitogens, or tuberculin purified protein derivative (PPD) was studied in cultures of separated human mononuclear cells or unseparated peripheral blood leukocytes (PBL). IFN-gamma was induced by
P D Benech et al.
The Journal of experimental medicine, 176(4), 1115-1123 (1992-10-01)
The human Fc gamma RI (CD64) is a high affinity receptor for the Fc portion of immunoglobulin (Ig), and its constitutively low expression on the cell surface of monocyte/macrophage and neutrophils is selectively upregulated by interferon gamma (IFN-gamma) treatment (Perussia
Jamie R Schoenborn et al.
Advances in immunology, 96, 41-101 (2007-11-06)
Interferon-gamma (IFN-gamma) is crucial for immunity against intracellular pathogens and for tumor control. However, aberrant IFN-gamma expression has been associated with a number of autoinflammatory and autoimmune diseases. This cytokine is produced predominantly by natural killer (NK) and natural killer
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