I3394
Interleukin-9 human
≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
Synonym(s):
IL-9
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About This Item
UNSPSC Code:
51111800
MDL number:
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
assay
≥97% (SDS-PAGE and N-terminal analysis)
form
lyophilized powder
mol wt
20-30 kDa
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL9(3578)
Biochem/physiol Actions
A T cell derived growth factor.
Interleukin-9 was first identified as a T cell derived growth factor. High affinity receptors for IL-9 are located on a variety of hematopoietic cells including T cells and macrophages.
Interleukin-9 was first identified as a T cell derived growth factor. High affinity receptors for IL-9 are located on a variety of hematopoietic cells including T cells and macrophages. There is high sequence homology between mouse and human IL-9. Overall sequence homology between human and mouse IL-9 cDNAs is 56% and 67% identity at the amino acid and nucleotide levels, respectively. MO7e cells are responsive to both mouse and human IL-9, while only mouse IL-9 can stimulate mouse P40-responsive cell lines. Mouse IL-9 enhances erythroid burst formation by normal mouse bone marrow cells. In addition, mouse IL-9 induces day 15 fetal thymocyte proliferation in the presence of IL-2 and enhances the mast cell growth elicited by IL-3 or IL-4. Mouse IL-9 also supports the growth of certain helper T cell clones. Human IL-9 supports erythroid colony formation and synergizes with IL-4 in the production of IgE and IgG.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
Analysis Note
The proliferative activity of recombinant human IL-9 is tested in culture using M07e cells.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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G C Avanzi et al.
British journal of haematology, 69(3), 359-366 (1988-07-01)
A new human leukaemic cell line (M-O7) with the phenotypic characteristics of CFU-mega is described. Its cells are positive for T200 leucocyte common antigen (LCA) and negative with MAbs recognizing T and B cells and mature myelomonocytic antigens. In contrast
Gabriella Ruocco et al.
Clinical science (London, England : 1979), 129(4), 291-303 (2015-02-24)
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by persistent inflammation orchestrated by cluster of differentiation (CD) 4 T helper (Th) cells. In particular, Th1 and Th17 cells amplify, whereas T regulatory (Treg) cells
Juan Liu et al.
The Journal of investigative dermatology, 134(7), 1903-1911 (2014-02-04)
The cytokine IL-9, derived primarily from T-helper 9 (Th9) lymphocytes, promotes expansion of the Th2 subset and is implicated in the mechanisms of allergic asthma. We hypothesize that IL-9 also has a role in human allergic contact dermatitis (ACD). To
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