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Merck
CN

I9031

Monoclonal Anti-Intracellular Adhesion Molecule 3 antibody produced in mouse

~1 mg/mL, clone 186-2G9, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-ICAM-3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01094485
Conjugate:
unconjugated
Clone:
186-2G9, monoclonal
Application:
FACS, IF (d), IHC, IP, WB
Citations:
2

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

186-2G9, monoclonal

form

buffered aqueous solution

mol wt

antigen 120 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

direct immunofluorescence: 2 μg using 1 mg protein lysate, flow cytometry: 2 μg using 1 mg protein lysate, immunohistochemistry: 2-4 μg/mL using human tonsil tissue sections, immunoprecipitation (IP): 2 μg using 1 mg protein lysate, western blot: 1-5 μg/mL

UniProt accession no.

P32942

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... ICAM3(3385)

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General description

The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. ICAM3 is found to be expressed on all leukocytes, including the resting leukocytes. The gene is mapped to human chromosome 19p13.2.

Immunogen

stimulated human leukocytes.

Biochem/physiol Actions

The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. It may also function in lymphocyte activation, as well as in adhesion.

Physical form

Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
117K1225
022K1179

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A R de Fougerolles et al.
The Journal of experimental medicine, 179(2), 619-629 (1994-02-01)
We have characterized the immunobiology of the interaction of intercellular adhesion molecule 3 (ICAM-3; CD50) with its counter-receptor, leukocyte function-associated antigen 1 (LFA-1; CD11a/CD18). Purified ICAM-3 supported LFA-1-dependent adhesion in a temperature- and cation-dependent manner. Activation of cells bearing LFA-1
P Kilgannon et al.
Genomics, 54(2), 328-330 (1998-11-26)
Intercellular adhesion molecule 5 (ICAM-5, telencephalin) is a cell adhesion molecule expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. Antibody studies in rodents and rabbits have demonstrated expression of this molecule on the cell

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