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Merck
CN

J4252

JWH-015

≥98% (HPLC), powder

Synonym(s):

(2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone

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About This Item

Empirical Formula (Hill Notation):
C23H21NO
CAS Number:
155471-08-2
Molecular Weight:
327.42
NACRES:
NA.77
PubChem Substance ID:
24278502
UNSPSC Code:
12352200
MDL number:
MFCD02094630

Key Documents

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Product Name

JWH-015, ≥98% (HPLC), powder

InChI

1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3

SMILES string

CCCn1c(C)c(C(=O)c2cccc3ccccc23)c4ccccc14

InChI key

LJSBBBWQTLXQEN-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

Quality Level

100

Gene Information

human ... CNR2(1269)
rat ... Cnr1(25248)

drug control

kontrollierte Droge in Deutschland
regulated under CDSA - not available from Sigma-Aldrich Canada

color

off-white

solubility

DMSO: >20 mg/mL (with heating)

storage temp.

−20°C

Related Categories

Application

JWH-015 has been used to study its effect on tumor-evoked pain behavior. It has also been used to study its protective effects on rat brain mitochondria upon paraquat exposure.

Biochem/physiol Actions

JWH-015 is a selective CB2 cannabinoid receptor agonist. JWH-015 is structurally classified as naphthoylindoles.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品
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Certificates of Analysis (COA)

Lot/Batch Number
041M4613V
109K47062
109K47061
109K4706
018K4712

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Joseph E Henriquez et al.
Toxicology and applied pharmacology, 369, 82-89 (2019-02-27)
Plasmacytoid dendritic cells (pDC) compose 0.2-0.5% of circulating leukocytes but play a significant role in mounting host immune responses. Elevated and chronic activation of pDC are implicated in autoimmune disease like systemic lupus erythematosus and rheumatoid arthritis. Δ9-tetrahydrocannabinol (THC) is
Intrathecal Administration of the Cannabinoid 2 Receptor Agonist JWH015 Can Attenuate Cancer Pain and Decrease mRNA Expression of the 2B Subunit of N-Methyl-D-Aspartic Acid
XiaoPing G, et al.
Journal of Cell Science, jcs-100925 (2012)
Protective effects of the synthetic cannabinoids CP55, 940 and JWH-015 on rat brain mitochondria upon paraquat exposure
Velez-Pardo C, et al.
Neurochemical Research, 35(9), 1323-1332 (2010)
Clinical Toxicology, An Issue of Emergency Medicine Clinics of North America, 4-4 (2014)
G Griffin et al.
European journal of pharmacology, 339(1), 53-61 (1998-02-05)
We have investigated whether there are cannabinoid CB2 receptors that can mediate cannabinoid-induced inhibition of electrically evoked contractions in the mouse vas deferens or guinea-pig myenteric plexus-longitudinal muscle preparation. Our results showed that mouse vas deferens and guinea-pig whole gut
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Articles

Synthetic Cannabinoid Analysis

A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.

Related Content

Product Information Sheet - J4252

Product Information Sheet

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