biological source
human
recombinant
expressed in E. coli
Assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.002-0.006 μg/mL ED50
mol wt
Mw ~8 kDa
storage condition
avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CCL22(6367)
Biochem/physiol Actions
Macrophage-Derived Chemokine (MDC) induces chemotaxis or calcium mobilization in dendritic cells, IL-2 activated cells, and activated T lymphocytes. MDC, also named stimulated T cell chemotactic protein (STCP-1), shows <35% identity to other CC chemokine family members. It is expressed in dendritic cells, macrophages, and activated monocytes. Expression is also detected in the tissues of thymus, lymph node, and appendix.
Physical form
Lyophilized from a 0.2 μm filtered solution in 20% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to chemoattract human T-lymphoblastoid CEM-NKr cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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