Key Documents

View All Documentation

M6524

Methoxamine hydrochloride

Name: Methoxamine hydrochloride
Brand: SIGMA

α1-adrenoceptor agonist

Synonym(s):

α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₇NO₃ · HCl

CAS Number:

61-16-5

Molecular Weight:

247.72

NACRES:

NA.77

PubChem Substance ID:

24277785

UNSPSC Code:

12352116

EC Number:

200-499-7

MDL number:

MFCD00058607

Quality level:

200

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

Methoxamine hydrochloride,

Quality Level

200

storage temp.

2-8°C

SMILES string

Cl[H].COc1ccc(OC)c(c1)C(O)C(C)N

InChI

1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H

InChI key

YGRFXPCHZBRUKP-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

α₁-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture.

Sven Francque et al.

Laboratory investigation; a journal of technical methods and pathology, 92(10), 1428-1439 (2012-08-15)

Non-alcoholic fatty liver disease can progress to steatohepatitis and fibrosis, and is also associated with impaired liver regeneration. The pathophysiology remains elusive. We recently showed that severe steatosis is associated with an increase in portal pressure, suggesting liver flow impairment.

Angiotensin-(1-7) reduces the perfusion pressure response to angiotensin II and methoxamine via an endothelial nitric oxide-mediated pathway in cirrhotic rat liver.

Chandana B Herath et al.

American journal of physiology. Gastrointestinal and liver physiology, 304(1), G99-108 (2012-10-23)

Recent studies have shown that, in cirrhosis, portal angiotensin-(1-7) [Ang-(1-7)] levels are increased and hepatic expression of angiotensin converting enzyme 2 (ACE2) and the Mas receptor are upregulated, but the effects of Ang-(1-7) on hepatic hemodynamics in cirrhosis have not

Chronic intermittent hypoxia aggravates intrahepatic endothelial dysfunction in cirrhotic rats.

Manuel Hernández-Guerra et al.

Hepatology (Baltimore, Md.), 57(4), 1564-1574 (2012-11-24)

Chronic intermittent hypoxia (CIH) occurs with obstructive sleep apnea syndrome (OSAS) and provokes systemic endothelial dysfunction, which is associated with oxidative stress and low nitric oxide (NO) bioavailability. Cirrhotic livers exhibit intrahepatic endothelial dysfunction, which is characterized by an impaired

The physiologic implications of isolated alpha(1) adrenergic stimulation.

Robert H Thiele et al.

Anesthesia and analgesia, 113(2), 284-296 (2011-04-27)

Phenylephrine and methoxamine are direct-acting, predominantly α(1) adrenergic receptor (AR) agonists. To better understand their physiologic effects, we screened 463 articles on the basis of PubMed searches of "methoxamine" and "phenylephrine" (limited to human, randomized studies published in English), as

Impact of systemically active neurohumoral factors on the erectile response of the rat.

Lindsay D MacKenzie et al.

The journal of sexual medicine, 8(9), 2461-2471 (2011-06-29)

Mean arterial pressure (MAP) and specific regulation of penile blood flow are the primary determinants of an erection. While this concept is well recognized, the differential relationship between systemically acting vasoactive factors on arterial pressure and erectile responses is not

View All Related Papers

Articles

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

Global Trade Item Number

SKU	GTIN
M6524-500MG	04061834061007
M6524-1G	04061834060994

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service