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M7068

MPP dihydrochloride hydrate

Name: MPP dihydrochloride hydrate
Brand: SIGMA

≥97% (HPLC), powder, estrogen receptor α agonist

Synonym(s):

1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride hydrate, Methyl-piperidino-pyrazole hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₃₁N₃O₃· 2 HCl · xH₂O

CAS Number:

911295-24-4

Molecular Weight:

542.50 (anhydrous basis)

UNSPSC Code:

51111800

PubChem Substance ID:

24724540

NACRES:

NA.77

MDL number:

MFCD06411603

Assay:

≥97% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

MPP dihydrochloride hydrate, ≥97% (HPLC), white, powder

Quality Segment

100

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: soluble ≥20 mg/mL

SMILES string

Cl.Cl.Cc1c(nn(-c2ccc(O)cc2)c1-c3ccc(OCCN4CCCCC4)cc3)-c5ccc(O)cc5

InChI

1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H

InChI key

FWDNPWVVRVSJQH-UHFFFAOYSA-N

Description

General description

Methyl-piperidino-pyrazole hydrate (MPP) is prepared from a methyl-pyrazole-triol (MPT), a pyrazole triol.

Application

MPP dihydrochloride hydrate has been used as an estrogen receptor α antagonist:

in human breast cancer MCF-7 cells
to pre-treat endometrial ex vivo organ cultures (EVOCs)
to treat pituitary glands to monitor luteinizing hormone secretion

Biochem/physiol Actions

MPP dihydrochloride is a specific estrogen receptor α antagonist.

Methyl-piperidino-pyrazole hydrate (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β. It promotes silibinin induced apoptosis in human breast cancer MCF-7 cells.

Specific estrogen receptor α antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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