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Merck
CN

MAK060

Fumarate Assay Kit

sufficient for 100 colorimetric tests

Synonym(s):

Fumarate Quantitative Assay Kit

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503

Key Documents

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Product Name

Fumarate Assay Kit, sufficient for 100 colorimetric tests

usage

sufficient for 100 colorimetric tests

detection method

colorimetric

relevant disease(s)

cancer

storage temp.

−20°C

Application

Fumarate Assay Kit has been used to determine the concentration of fumarate in samples.
Suitable for the detection of fumarate in a variety of samples including tissue, cells and serum

Biochem/physiol Actions

Fumarate is determined by an enzyme assay, which results in a colorimetric (450 nm) product, proportional to the fumarate present.

General description

Fumarate is a tricarboxylic acid (TCA) cycle intermediate formed by the oxidation of succinate by succinate dehydrogenase. In the mammalian liver, Fumarate is also a product of the Urea cycle where its release in the cytosol leads to its conversion into malate and subsequently oxaloacetate while generating NADH in the cytosol. Deficiencies in fumarate hydratase are associated with increased cellular concentrations of fumarate and increased incidences of renal cell cancer. This is most likely due to fumarate-mediated upregulation of HIF1. The Fumarate Assay Kit provides a convenient tool for sensitive detection of the fumarate in a variety of samples.

signalword

Danger

pictograms

Corrosion
GHS05

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

Regulatory Information

含少量动物源组分生物产品
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
8M19K06330
8F09K06330
8H02K06330
8B04K06330
7J03K06330

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