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N115

Naltrindole hydrochloride

Name: Naltrindole hydrochloride
Brand: SIGMA

≥97.5% (HPLC), solid, δ-opioid receptor antagonist

Synonym(s):

NTI hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₆N₂O₃ · HCl

CAS Number:

111469-81-9

Molecular Weight:

450.96

UNSPSC Code:

12352200

PubChem Substance ID:

24278062

NACRES:

NA.77

MDL number:

MFCD00069313

Form:

solid

Quality level:

100

Storage condition:

desiccated

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Product Name

Naltrindole hydrochloride, solid

form

solid

Quality Level

100

storage condition

desiccated

color

off-white

solubility

methanol: 4.5 mg/mL, H₂O: 8 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7ccccc7c6C[C@@]35O)CC8CC8

InChI

1S/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H/t20-,24+,25+,26-;/m1./s1

InChI key

KNJKRQXCFJCQHC-IDRHMUJXSA-N

Gene Information

human ... OPRD1(4985)

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

Highly selective, non-peptide δ-opioid receptor antagonist that crosses the blood-brain barrier.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.

W Bilecki et al.

European journal of pharmacology, 390(1-2), 1-6 (2000-03-10)

A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway. Regulation of CREB and subsequent changes in gene expression may underlie some long-term

Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line.

J L Nano et al.

Pflugers Archiv : European journal of physiology, 439(5), 547-554 (2000-04-14)

Using 3H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (3H-DADLE) as a radioligand, delta-opioid binding sites on the IRD 98 rat epithelial cell line were identified. These sites were found to be reversible, saturable, specific and displayed high affinity for DADLE. Scatchard analysis revealed a dissociation constant

Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.

P S Portoghese et al.

European journal of pharmacology, 146(1), 185-186 (1988-01-27)

Global Trade Item Number

SKU	GTIN
N115-5MG	04061832557366
N115-50MG	04061832557359
N115-10MG	04061832557342

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