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N1771

nor-Binaltorphimine dihydrochloride

Name: <I>nor</I>-Binaltorphimine dihydrochloride
Brand: SIGMA

≥98% (TLC), solid, κ-opioid receptor antagonist

Synonym(s):

nor-BNI dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₄₀H₄₃N₃O₆ · 2HCl

CAS Number:

113158-34-2

Molecular Weight:

734.71

UNSPSC Code:

12352200

PubChem Substance ID:

24278018

NACRES:

NA.77

MDL number:

MFCD00069374

Form:

solid

Quality level:

200

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Product Name

nor-Binaltorphimine dihydrochloride,

form

solid

Quality Level

200

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7[C@@H]8Oc9c(O)ccc%10C[C@H]%11N(CC[C@@]8(c9%10)[C@@]%11(O)Cc7c6C[C@@]35O)CC%12CC%12)CC%13CC%13

InChI

1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1

InChI key

JOJPJLHRMGPDPV-LZQROVCBSA-N

Gene Information

human ... OPRK1(4986)

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Highly selective k-opioid receptor antagonist. nor-Binaltorphimine has antidepressant properties.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

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Ligand binding profiles of U-69, 593-sensitive and-insensitive sites in human cerebral cortex membranes: evidence of kappa opioid receptors heterogeneity.

K W Kim et al.

Life sciences, 58(19), 1671-1679 (1996-01-01)

Receptor binding studies were performed to characterize the properties of subtypes of kappa opioid receptors in membrane preparations of human cerebral cortex. [3H]U69,593 ([3H]U69), a selective kappa 1-agonist, and [3H]diprenorphine ([3H]DIP), a non-selective opioid antagonist, in the presence of 1

Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay.

J G Wettstein et al.

Pharmacology, biochemistry, and behavior, 53(2), 411-416 (1996-02-01)

The antinociceptive effects of mu and kappa agonists were examined after the systemic administration of the opioid antagonists nor-binaltorphimine (nor-BNI) and naloxone in the late response or tonic nociceptive phase of the mouse formalin assay. Initially, SC morphine (ED50, 0.97

Kappa opioid receptor activation increases thermogenic energy expenditure which drives increased feeding.

Aaron L Cone et al.

iScience, 26(7), 107241-107241 (2023-07-24)

Opioid receptors, including the kappa opioid receptor (KOR), exert control over thermoregulation and feeding behavior. Notably, activation of KOR stimulates food intake, leading to postulation that KOR signaling plays a central role in managing energy intake. KOR has also been

Mouse strain differences in immunosuppression by opioids in vitro.

T K Eisenstein et al.

The Journal of pharmacology and experimental therapeutics, 275(3), 1484-1489 (1995-12-01)

An in vitro assay was used to compare the effect of opioids on antibody production by splenocytes from C3HeB/FeJ, C57BL/6J, C57BL/6ByJ and B6C3F1/J mice immunized with sheep red blood cells (SRBC). Spleen cells were removed from mice that had been

Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: Behavioral and BDNF mRNA expression studies

Zhang H, et al.

European Journal of Pharmacology, 570(1-3), 89-96 (2007)

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Global Trade Item Number

SKU	GTIN
N1771-10MG	04061834109808

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