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N4143

Neurokinin B

≥95% (HPLC)

Synonym(s):

β-Neurokinin, Neuromedin K

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About This Item

Empirical Formula (Hill Notation):
C55H79N13O14S2
CAS Number:
86933-75-7
Molecular Weight:
1210.42
NACRES:
NA.32
PubChem Substance ID:
24897694
UNSPSC Code:
51111800
MDL number:
MFCD00133665
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
200
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Quality Level

200

assay

≥95% (HPLC)

form

powder

UniProt accession no.

Q9UHF0

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CC(O)=O)NC(=O)C(Cc3cnc[nH]3)NC(=O)C(CCSC)NC(=O)C(N)CC(O)=O)C(C)C)C(N)=O

InChI

1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)

InChI key

NHXYSAFTNPANFK-UHFFFAOYSA-N

Gene Information

human ... TAC3(6866)

Related Categories

Biochem/physiol Actions

Neurokinin B is a ten-residue peptide. It is an endogenous tachykinin agonist with preference for the NK-3 receptor. It is a potent bronchoconstrictor and may have a neuromodulatory role in the brain. Neurokinin B has a role in slow synaptic or non-synaptic communication.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000435218
0000435218
0000226747
0000226749
0000226538

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Neurokinin B- and specific tachykinin NK3 receptor agonists-induced airway hyperresponsiveness in the guinea-pig
Samira D
British Journal of Pharmacology (2000)
The Tachykinin Peptide Neurokinin B Binds Copper Forming an Unusual [CuII(NKB)2] Complex and Inhibits Copper Uptake into 1321N1 Astrocytoma Cells
ACS Chemical Neuroscience (2013)
Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep
Endocrinology (2010)
Hiroaki Okamura et al.
Advances in experimental medicine and biology, 784, 297-323 (2013-04-04)
The reproductive neuropeptide gonadotropin-releasing hormone (GnRH) has two modes of secretion. Besides the surge mode, which induces ovulation in females, the pulse mode of GnRH release is essential to cause various reproductive events in both sexes, such as spermatogenesis, follicular
Michael N Lehman et al.
Endocrinology, 151(8), 3479-3489 (2010-05-27)
Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has been shown to play a critical role in the central control of reproduction.
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Global Trade Item Number

SKUGTIN
N4143-.5MG04061832677323
N4143-5MG04061832272672
N4143-1MG04061826153024

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