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N4267

Neurokinin A

Name: Neurokinin A
Brand: SIGMA

≥97% (HPLC), tachykinin peptide, powder

Synonym(s):

α-Neurokinin, Neuromedin L, Substance K

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About This Item

Linear Formula:

C₅₀H₇₉N₁₃O₁₅S

CAS Number:

86933-74-6

Molecular Weight:

1133.32

UNSPSC Code:

51111800

PubChem Substance ID:

24897700

NACRES:

NA.32

MDL number:

MFCD00167560

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

200

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Product Name

Neurokinin A, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ≥70%

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)Cc2cnc[nH]2)C(C)O)C(C)C)C(N)=O

InChI

1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)

InChI key

HEAUFJZALFKPBA-UHFFFAOYSA-N

Gene Information

human ... TAC1(6863)

Related Categories

Bioactive Small Molecules

Bioactive Small Molecule Agonists

General description

Neurokinin A is an 11 amino acid peptide. It is a member of tachykinin family, which includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1. The gene encoding neurokinin A is localized on human chromosome 7q21.3.

Biochem/physiol Actions

Neurokinin A improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, triggers glandular secretion and controls autonomic reflexes. Neurokinin A plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000398800

0000223867

0000161700

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Delineation of a de novo 7q21.3q31.1 Deletion by
CGH-SNP Arrays in a Girl with Multiple Congenital
Anomalies Including Severe Glaucoma

L. Martinez-Jacobo

Molecular Syndromology (2013)

Quantitative mass spectrometry analysis reveals that deletion of the TRPV1 receptor in mice alters substance P and neurokinin A expression in the central nervous system.

Floriane Pailleux et al.

Neurochemical research, 37(12), 2678-2685 (2012-08-11)

Vanilloid receptors have a central role in the processing of nociceptive stimuli. TRPV1 null mice showed significant decrease in response to heat noxious stimuli. However, thermal sensitivity is still present suggesting that the TRPV1 is not an exclusive transducer of

Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFN?/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis

Janek V

Journal of Neuroimmune Pharmacology (2015)

Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A.

Y Chang et al.

The Journal of pharmacology and experimental therapeutics, 294(1), 147-154 (2000-06-28)

Selective tachykinin agonists were used to identify cardiac and coronary responses mediated by specific tachykinin receptor subtypes in isolated, perfused guinea pig hearts. Receptor desensitization with selective agonists and blockade with selective antagonists were used to determine the role of

A role for endogenous peptide YY in tachykinin NK(2) receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.

Shu-ichi Kojima et al.

British journal of pharmacology, 167(6), 1362-1368 (2012-07-05)

The colon-derived peptide hormone, peptide YY (PYY), regulates colonic motility, secretion and postprandial satiety; but little is known about the influence of endogenous PYY on 5-HT release from colonic mucosa. Tachykinin NK(2) receptor-selective agonist, βAla-NKA-(4-10) induces 5-HT release from guinea

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Global Trade Item Number

SKU	GTIN
N4267-1MG	04061834116530
N4267-.5MG	04061832677361

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