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O1877

Ochratoxin A

Name: Ochratoxin A
Brand: SIGMA

from Petromyces albertensis, ≥98% (HPLC), powder, mycotoxin

Synonym(s):

N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₈ClNO₆

CAS Number:

303-47-9

Molecular Weight:

403.81

NACRES:

NA.77

PubChem Substance ID:

24897954

UNSPSC Code:

12352200

MDL number:

MFCD00078079

Beilstein/REAXYS Number:

1301486

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Ochratoxin A, from Petromyces albertensis, ≥98% (HPLC)

biological source

Petromyces albertensis

Quality Segment

300

assay

≥98% (HPLC)

form

powder

impurities

Benzene, free

solubility

ethanol: soluble

mode of action

enzyme | inhibits, protein synthesis | interferes

storage temp.

2-8°C

SMILES string

C[C@@H]1Cc2c(Cl)cc(c(O)c2C(=O)O1)C(=O)N[C@@H](Cc3ccccc3)C(O)=O

InChI

1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1

InChI key

RWQKHEORZBHNRI-BMIGLBTASA-N

Description

Application

Ochratoxin A has been used as a mycotoxin:

to test its effect on metabolism and hypoxia in human embryonic kidney (HEK293) cells
to test its cytotoxic effects in bovine mammary epithelial cells
as a standard for gamma radiation studies with food products and in cytotoxic studies using Hep G2 cells

Biochem/physiol Actions

Ochratoxin A (OTA), a renal toxin, is produced majorly by Aspergillus and Penicillium fungal species. It is immunotoxic, teratogenic myelotoxic, and mutagenic. It effectively interrupts the intestinal barrier functions. OTA displays a long elimination half-life and stimulates the major inflammatory cytokines release.

Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca²⁺ pump activity.

Preparation Note

This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM).

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H351

pcodes

P201 - P264 - P280 - P301 + P310 + P330 - P308 + P313 - P501

Hazard Classifications

Acute Tox. 2 Oral - Carc. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Articles

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

Global Trade Item Number

SKU	GTIN
O1877-25MG	04061833273272
O1877-5MG	04061838446442
O1877-1MG	04061838446435