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O5889

Opipramol dihydrochloride

Name: Opipramol dihydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₉N₃O · 2HCl

CAS Number:

909-39-7

Molecular Weight:

436.42

NACRES:

NA.77

PubChem Substance ID:

24724565

UNSPSC Code:

12352200

EC Number:

213-000-2

MDL number:

MFCD00941483

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

yellow

solubility

H₂O: ~24 mg/mL

SMILES string

Cl[H].Cl[H].OCCN1CCN(CCCN2c3ccccc3C=Cc4ccccc24)CC1

InChI

1S/C23H29N3O.2ClH/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26;;/h1-4,6-11,27H,5,12-19H2;2*1H

InChI key

DLTOEESOSYKJBK-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Agonists

General description

Opipramol acts as an antidepressant and is chemically similar to tricyclic antidepressants. It is an atypical anxiolytic and antidepressant drug. Opipramol mainly acts on sigma receptors. It is usually found to be much effective in depressive disorder. It has the ability to prevent histamine, serotonin, dopamine and alpha-1 adrenergic receptors.

Biochem/physiol Actions

σ₁/σ₂ opioid receptor agonist; an antagonist at D₂, 5HT₂ and H₁ receptors; atypical antidepressant, antipsychotic and anxiolytic

Atypical antidepressant, antipsychotic and anxiolytic

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H410

pcodes

P264 - P270 - P273 - P301 + P312 - P391 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000541127

0000268262

0000268261

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Gastroprotective and antioxidant effects of opipramol on indomethacin-induced ulcers in rats.

Hakan Dursun et al.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129(7), 861-869 (2009-07-03)

Tricyclic antidepressants are particularly useful in the treatment of endogenous depression. Since the 1950s, tricyclic antidepressants (TCAs) have also been used for the treatment of gastric ulcer disease. Many TCAs have been evaluated for their antiulcer effects, but there are

Update Opipramol

Gahr M, et al.

Fortschritte der Neurologie-Psychiatrie, 139-145 (2017)

Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group.

H J Möller et al.

Journal of clinical psychopharmacology, 21(1), 59-65 (2001-02-24)

Opipramol, a drug widely prescribed in Germany, is a tricyclic compound with no reuptake-inhibiting properties. However, it has pronounced D2-, 5-HT2-, and H1-blocking potential and high affinity to sigma receptors (sigma-1 and sigma-2). In early controlled trials, anxiolytic effects were

[Opipramol in behavioral pharmacologic anxiety and depression models].

C Gentsch

Fortschritte der Neurologie-Psychiatrie, 66 Suppl 1, S17-S20 (1999-01-29)

Opipramol as nighttime medication.

Ulrich Leutgeb

Deutsches Arzteblatt international, 106(18), 321-321 (2009-06-24)

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Global Trade Item Number

SKU	GTIN
O5889-25MG	04061832557731
O5889-100MG	04061832557724

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