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P6656

Promazine hydrochloride

Name: Promazine hydrochloride
Brand: SIGMA

Synonym(s):

10-(3-Dimethylaminopropyl)phenothiazine hydrochloride

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About This Item

Linear Formula:

C₁₇H₂₀N₂S · HCl

CAS Number:

53-60-1

Molecular Weight:

320.88

UNSPSC Code:

41116107

NACRES:

NA.77

PubChem Substance ID:

24278645

EC Number:

200-179-7

Beilstein/REAXYS Number:

3753230

MDL number:

MFCD00058535

Form:

solid

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Properties

form

solid

originator

Baxter

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccccc13

InChI

1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H

InChI key

JIVSXRLRGOICGA-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

Description

General description

Promazine hydrochloride (PMZ) belongs to the phenothiazine drug family. Promazine is a D2 dopamine receptor antagonist and has antipsychotic and anticholinergic functionality. It is used for pain management and is also used for treating hypersensitivity reactions.

Application

Promazine hydrochloride has been used in conductivity and surface tension measurements and for testing inhibition of feline coronavirus (FCoV) in Felis catus whole fetus-4 (fcwf-4) cells.

Biochem/physiol Actions

D₂ dopamine receptor antagonist; phenothiazine antipsychotic.

Features and Benefits

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H317

pcodes

P280 - P301 + P312 + P330 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Promazine in the treatment of delusional parasitosis.

Cubala W, et al.

Psychiatria Danubina, 23(2.), 198-199 (2011)

Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus.

Hsieh LE, et al.

Antiviral Research, 88(1), 25-30 (2010)

The influence of selective serotonin reuptake inhibitors on the plasma and brain pharmacokinetics of the simplest phenothiazine neuroleptic promazine in the rat.

W A Daniel et al.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 9(4), 337-344 (1999-07-28)

The aim of the present study was to investigate a possible impact of the three selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine and sertraline on the pharmacokinetics of promazine in a steady state in rats. Promazine was administered twice a

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Global Trade Item Number

SKU	GTIN
P6656-25G	04061832092812