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Merck
CN

P6656

Promazine hydrochloride

Synonym(s):

10-(3-Dimethylaminopropyl)phenothiazine hydrochloride

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About This Item

Linear Formula:
C17H20N2S · HCl
CAS Number:
53-60-1
Molecular Weight:
320.88
UNSPSC Code:
41116107
NACRES:
NA.77
PubChem Substance ID:
24278645
EC Number:
200-179-7
Beilstein/REAXYS Number:
3753230
MDL number:
MFCD00058535

Key Documents

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InChI key

JIVSXRLRGOICGA-UHFFFAOYSA-N

InChI

1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccccc13

form

solid

originator

Baxter

storage temp.

2-8°C

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

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Application

Promazine hydrochloride has been used in conductivity and surface tension measurements and for testing inhibition of feline coronavirus (FCoV) in Felis catus whole fetus-4 (fcwf-4) cells.

Biochem/physiol Actions

D2 dopamine receptor antagonist; phenothiazine antipsychotic.

Features and Benefits

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Promazine hydrochloride (PMZ) belongs to the phenothiazine drug family. Promazine is a D2 dopamine receptor antagonist and has antipsychotic and anticholinergic functionality. It is used for pain management and is also used for treating hypersensitivity reactions.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H317

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ1387
BCCF3817
BCCC4389
BCBR3517V
BCBV5669

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Study of the interaction between promazine hydrochloride and surfactant (conventional/gemini) mixtures at different temperatures.
Rub MA, et al.
Journal of Solution Chemistry, 43(5), 930-949 (2014)
Promazine in the treatment of delusional parasitosis.
Cubala W, et al.
Psychiatria Danubina, 23(2.), 198-199 (2011)
Determination of thiazinamium, promazine and promethazine in pharmaceutical formulations using a CZE method.
Lara FJ, et al.
Analytica Chimica Acta, 535(1-2), 101-108 (2005)
W A Daniel et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 9(4), 337-344 (1999-07-28)
The aim of the present study was to investigate a possible impact of the three selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine and sertraline on the pharmacokinetics of promazine in a steady state in rats. Promazine was administered twice a
Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus.
Hsieh LE, et al.
Antiviral Research, 88(1), 25-30 (2010)
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