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Merck
CN

PLA0010

Goat anti-RENT1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

ATP-dependent helicase RENT1, HUPF1, KIAA0221, NORF1, RENT1, UP Frameshift 1, UPF1 regulator of nonsense transcripts homolog, UPF1 regulator of nonsense transcripts homolog (yeast), delta helicase, nonsense mRNA reducing factor 1, nonsense mediated mRNA decay factor, nonsense mediated mRNA decay factor (C. elegans), pNORF1, regulator of nonsense transcripts 1, smg-2, smg-2 homolog, up-frameshift mutation 1 homolog, up-frameshift suppressor 1 homolog, yeast Upf1p homolog

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

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Product Name

Goat anti-RENT1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.

biological source

goat

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

concentration

1 mg/mL

technique(s)

immunoprecipitation (IP): 2-10 μg/mL
western blot: 1:2,000-1:10000

accession no.

NP_002902.2

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

goat ... UPF1(5976)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

The epitope recognized by PLA0010 maps to a region between residue 1075 and the C-terminus (residue 1118) of human Regulator of Nonsense Transcripts 1 (up-frameshift mutation 1 homolog) using the numbering given in entry NP_002902.2 (GeneID 5976).

Other Notes

RENT1, also known as UPF1, is a key regulator of the nonsense-mediated mRNA decay (NMD) pathway. The NMD pathway eliminates mRNAs that prematurely terminate during translation and may serve to protect the cells from dominant-negative effects of truncated proteins, or as a means to regulate protein expression. RENT1 is an ATP-dependent 5′- 3′ RNA helicase and ATPase that localizes to the cytoplasm and is part of a post-splicing multiprotein complex as well as an mRNA decay complex.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Lot/Batch Number
1

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