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Merck
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PLA0100

Rabbit anti-MLL1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

ALL-1, CDK6/MLL fusion protein, CXXC-type zinc finger protein 7, CXXC7, HRX, HTRX1, MLL, MLL-AF4 der(11) fusion protein, MLL-AF9, MLL/ENL fusion protein, MLL/GAS7, MLL/GAS7 fusion protein, MLL/GMPS fusion protein, MLL/hCDCrel fusion protein, MLL1, MLL1A, Myeloid/lymphoid or mixed-lineage leukemia, TET1-MLL, TRX1, WDSTS, lysine (K)-specific methyltransferase 2A, lysine N-methyltransferase 2A, mixed lineage leukemia 1, rearranged MLL protein, trithorax-like protein, zinc finger protein HRX

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About This Item

NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ChIP, IP, WB
Citations:
4

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

ChIP: 1- 5 μg, immunoprecipitation (IP): 2-5 μg/mg, western blot: 1:2,000-1:10,000

accession no.

Q03164

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rabbit ... MLL1(4297)

General description

MLL1 (mixed-lineage leukemia) gene is also referred as KMT2A (lysine methyltransferase 2A) and is located on human chromosome locus 11q23.3.

Immunogen

The epitope recognized by PLA0100 maps to a region between residues 2725 and 2775 of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297).

Biochem/physiol Actions

MLL1 (mixed-lineage leukemia) is a histone methyltransferase and has a role in embryogenesis and hematopoiesis. MLL1 is a transcriptional co-activator and regulates epigenetic gene expression through chromatin modification. MLL1 is associated with NF-κB (nuclear factor kappa B) pathway- induced brain tumor proliferation. On the other hand, MLL1 is known to prevent metastasis and invasion in cervical cancer.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

MLL1 (mixed lineage leukemia 1) has been found to participate in a multitude of chromosomal translocations that are associated with a variety of hematologic malignancies. MLL1 functions as a transcriptional regulator and plays and important role in HOX gene expression during embryonic development.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
低风险生物材料
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Certificates of Analysis (COA)

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Yan Jin et al.
PLoS biology, 19(6), e3001297-e3001297 (2021-06-11)
Recent studies have shown that long noncoding RNAs (lncRNAs) are critical regulators in the central nervous system (CNS). However, their roles in the cerebellum are currently unclear. In this work, we identified the isoform 204 of lncRNA Gm2694 (designated as
Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.
Tarlock K, et al.
Clinical Cancer Research, 23(14), 3649-3656 (2017)
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability.
Grey W, et al.
Biochimica et Biophysica Acta, 1865(1), 105-116 (2018)
KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway.
Zhang C, et al.
Cell Death & Disease, 8(7), e2940-e2940 (2017)

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