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PLA0108

Sigma-Aldrich

Rabbit anti-DDB1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
DDBA, DDB p127 subunit, XAP-1, XPE-BF, XPCE, damage-specific DNA binding protein 1 (127kD), UV-DDB1, UV-DDB 1, XPE, damage-specific DNA binding protein 1, HBV X-associated protein 1, 127kDa, xeroderma pigmentosum group E-complementing protein, Damage-specific DNA-binding protein 1, UV-damaged DNA-binding protein 1, DNA damage-binding protein a, XAP1, XPE-binding factor, UV-damaged DNA-binding factor
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

mouse, human

concentration

0.2 mg/mL

application(s)

immunohistochemistry: 1:500- 1:2,000
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:1,000- 1:10,000

accession no.

Q13289

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... DDB1(1642)

Immunogen

The epitope recognized by PLA0108 maps to a region between residue 1100 and the C-terminus (residue 1140) of human damage-specific DNA binding protein 1 using the numbering given in TrEMBL entry Q13289 (GeneID 1642).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

DDB1 (DNA Damage Binding Protein 1) is a subunit of the DNA damage-binding protein complex (DDB) involved in DNA repair. As part of a complex with Cul4-based ubiquitin ligase, Cul4-Ddb1 can directly modify chromatin through the ubiquitination of histones as well as ubiquitinate other chromatin bound factors. A deficiency in Cul4-Ddb1 ubiquitin ligase has been associated with xeroderma pigmentosum, a heritable disease characterized by defects in nucleotide excision repair and skin cancer development.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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