PLA0221
Rabbit anti-ORC1 Antibody, Affinity Purified
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Synonym(s):
HSORC1, ORC1L, PARC1, S. cerevisiae, homolog-like, origin recognition complex, origin recognition complex 1, replication control protein 1, subunit 1, subunit 1 (yeast homolog)-like, subunit 1 homolog, subunit 1 homolog (S. cerevisiae), subunit 1-like (yeast)
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
technique(s)
immunoprecipitation (IP): 2-5 μg/mg, western blot: 1:2,000- 1:10,000
accession no.
NP_004144.2
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
rabbit ... ORC1(4998)
General description
Origin recognition complex 1 (ORC1) is the largest subunit of ORC. The subunits are widely expressed in the human lung, bones, kidney, and uterus. The ORC1 gene is mapped to human chromosome 1p32.3.
Immunogen
The epitope recognized by PLA0221 maps to a region between residue 811 and 861 of human origin recognition complex subunit 1 using the numbering given in entry NP_004144.2 (GeneID 4998).
Application
Rabbit anti-ORC1 Antibody, Affinity Purified has been used in immunoblotting (1:2,000).
Biochem/physiol Actions
The origin recognition complex (ORC) plays a key role in DNA replication. ORC1 is degraded in the S phase and re-synthesized in the G1 phase of the cell cycle. ORC1 is responsible for cell proliferation, apoptosis, invasion, and migration. ORC1 regulates cyclin E1 (CCNE1) gene expression and is involved in genomic maintenance. Downregulation of ORC1 and cyclins cause Meier–Gorlin syndrome.
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
ORC1 (origin recognition complex, subunit 1) is one of six subunits that make up the origin of recognition complex (ORC). The ORC serves as a scaffold for proteins involved in the initiation of DNA replication. Very recently, ORC1 has been found to perform a function independent of its role in DNA replication. In a screen using siRNAs for human ORC proteins to assess their roles in centrosome biology, it was found that ORC1 plays a key role in controlling centriole and centrosome copy number in human cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Boxiao Wang et al.
Protein science : a publication of the Protein Society, 28(9), 1727-1733 (2019-07-17)
Progression of cell cycle is regulated by sequential expression of cyclins, which associate with distinct cyclin kinases to drive the transition between different cell cycle phases. The complex of Cyclin A with cyclin-dependent kinase 2 (CDK2) controls the DNA replication
Xinxin Wang et al.
Cancer management and research, 10, 6971-6984 (2018-12-28)
Centromere protein U (CENPU) abnormally exhibits high expression in various types of human tumor tissues and participates in tumor progression; however, its expression pattern and biological function in lung cancer have not yet been elucidated. In the present study, we
Wenmin Xiong et al.
Molecular and cellular probes, 49, 101496-101496 (2019-12-24)
Origin recognition complex subunit 1(ORC1) is reported to be closely associated with the cell cycle. However, studies on the role of ORC1 in glioma remain undefined. The aim of the present study was to determine whether ORC1 affects cell migration
Philippe Coulombe et al.
Nature communications, 10(1), 2426-2426 (2019-06-05)
DNA replication initiation is a two-step process. During the G1-phase of the cell cycle, the ORC complex, CDC6, CDT1, and MCM2-7 assemble at replication origins, forming pre-replicative complexes (pre-RCs). In S-phase, kinase activities allow fork establishment through (CDC45/MCM2-7/GINS) CMG-complex formation.
Cari L Graber-Feesl et al.
Molecular cancer research : MCR, 17(8), 1687-1698 (2019-05-23)
Mitotic DNA synthesis is a recently discovered mechanism that resolves late replication intermediates, thereby supporting cell proliferation under replication stress. This unusual form of DNA synthesis occurs in the absence of RAD51 or BRCA2, which led to the identification of
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