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Merck
CN

PLA0292

Goat anti-RNA Polymerase II Antibody, Affinity Purified

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Synonym(s):

220kDa, DNA-directed RNA polymerase II largest subunit, DNA-directed RNA polymerase II subunit A, DNA-directed RNA polymerase III largest subunit, POLR2, POLRA, RNA polymerase II 220 kd subunit, RNA polymerase II subunit B1, RNA-directed RNA polymerase II subunit RPB1, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1, polymerase (RNA) II (DNA directed) polypeptide A

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

concentration

1 mg/mL

technique(s)

immunoprecipitation (IP): 2- 10 μg/mg
western blot: 1:1,000- 1:5,000

accession no.

NP_000928.1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... POLR2A(5430)

Immunogen

The epitope recognized by PLA0292 maps to a region within the C-terminal repeat of human RNA Polymerase II using the reference sequence NP_000928.1 (GeneID 5430).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

The RNA polymerase II subunit B1 (RPB1) is the largest subunit of the RNA polymerase II core complex. RNA polymerase II holoenzyme functions to transcribe DNA into messenger RNA in eukaryotes. RPB1 forms the DNA binding domain of the polymerase that forms a cleft that grabs the incoming DNA template to translocate the holoenzyme across the RNA-DNA hybrid.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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James P Wells et al.
PLoS genetics, 18(12), e1010309-e1010309 (2022-12-09)
DNA replication is a vulnerable time for genome stability maintenance. Intrinsic stressors, as well as oncogenic stress, can challenge replication by fostering conflicts with transcription and stabilizing DNA:RNA hybrids. RAD18 is an E3 ubiquitin ligase for PCNA that is involved
Jianfei Zhang et al.
International journal of oral science, 11(2), 12-12 (2019-03-19)
Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation, and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound abnormalities of the craniofacial tissues. The aim of this study was
Emily Yun-Chia Chang et al.
Nature communications, 10(1), 4265-4265 (2019-09-21)
Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-loops. To comprehensively identify anti-R-loop mechanisms, we performed a genome-wide trigenic
Sangin Kim et al.
Nucleic acids research, 48(13), 7218-7238 (2020-06-17)
R-loops are formed when replicative forks collide with the transcriptional machinery and can cause genomic instability. However, it is unclear how R-loops are regulated at transcription-replication conflict (TRC) sites and how replisome proteins are regulated to prevent R-loop formation or

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