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PRS2337

Sigma-Aldrich

Anti-IKAP antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-IKBKAP, Anti-IKK complex-associated protein, Anti-Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

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About This Item

MDL number:
MFCD04118553
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 134-147 kDa

species reactivity

mouse, human

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

O95163

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IKBKAP(8518)

General description

IKAP (IKK-complex-associated protein) is considered as a subunit of the RNA Pol II elongator complex. It is also known as IKBKAP (Ikappakinase complex-associated protein or human elongator factor 1) and ELP1 (elongator protein-1). It has 37 exons and codes for 1332 amino acid IKAP protein, that is of ~150KD. It is present in most of the tissues. It is mapped to chromosome 9q31.

Immunogen

a 16 amino acid peptide from near the carboxy-terminus of human IKAP.

Biochem/physiol Actions

Mutations in IKAP cause familial dysautonomia. It helps to conserve the proliferation of neural precursor and blocks its unexpected differentiation into neurons. It plays an important role in cell motility and migration.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP2337.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
23370004
23370201
2337-0201

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Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation.
Lefler S, et al.
PLoS ONE, 10(10):e0138807 (2015)
IKAP/Elp1 is required in vivo for neurogenesis and neuronal survival, but not for neural crest migration.
Hunnicutt B J,et al.
PLoS ONE, 7(2):e32050 (2012)

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