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Merck
CN

PZ0159

MCOPPB trihydrochloride hydrate

>98% (HPLC)

Synonym(s):

1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C26H40N4 · 3 HCl · xH2O
CAS Number:
1028969-49-4
Molecular Weight:
518.01 (anhydrous basis)
UNSPSC Code:
51111800
PubChem Substance ID:
329823741
NACRES:
NA.77

Key Documents

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SMILES string

O.Cl.Cl.Cl.CC1(CCCCCCC1)N2CCC(CC2)n3c(nc4ccccc34)[C@@H]5CCCNC5

InChI

1S/C26H40N4.3ClH.H2O/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21;;;;/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3;3*1H;1H2

InChI key

UQBVSGBDJOJHIP-UHFFFAOYSA-N

assay

>98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

H2O: ≥13 mg/mL

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
Potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000439280
0000439280
0000202000
0000183831
0000183833

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Marco Raffaele et al.
GeroScience (2021-11-26)
Accumulation of senescent cells may drive age-associated alterations and pathologies. Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here, we performed a high-throughput automatized screening (HTS) of the commercial LOPAC®Pfizer library on aphidicolin-induced senescent human fibroblasts, to identify

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