PZ0159
MCOPPB trihydrochloride hydrate
>98% (HPLC)
别名:
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate
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关于此项目
经验公式（希尔记法）:
C26H40N4 · 3 HCl · xH2O
化学文摘社编号:
分子量:
518.01 (anhydrous basis)
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
>98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: ≥13 mg/mL
storage temp.
room temp
SMILES string
O.Cl.Cl.Cl.CC1(CCCCCCC1)N2CCC(CC2)n3c(nc4ccccc34)[C@@H]5CCCNC5
InChI
1S/C26H40N4.3ClH.H2O/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21;;;;/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3;3*1H;1H2
InChI key
UQBVSGBDJOJHIP-UHFFFAOYSA-N
Biochem/physiol Actions
MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
Potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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Marco Raffaele et al.
GeroScience (2021-11-26)
Accumulation of senescent cells may drive age-associated alterations and pathologies. Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here, we performed a high-throughput automatized screening (HTS) of the commercial LOPAC®Pfizer library on aphidicolin-induced senescent human fibroblasts, to identify
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| PZ0159-25MG | 04061832559407 |
| PZ0159-5MG | 04061832559414 |