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Q1004

Quipazine maleate salt

Name: Quipazine maleate salt
Brand: SIGMA

serotonin/5-hydroxytryptamine-2A/C receptor agonist

Synonym(s):

2-(1-Piperazinyl)quinoline maleate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₅N₃ · C₄H₄O₄

CAS Number:

5786-68-5

Molecular Weight:

329.35

NACRES:

NA.77

PubChem Substance ID:

24278122

UNSPSC Code:

12352200

EC Number:

227-314-2

MDL number:

MFCD00133796

Quality level:

200

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Product Name

Quipazine maleate salt,

Quality Level

200

solubility

H₂O: soluble, alcohol: soluble, dilute aqueous acid: soluble

storage temp.

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.C1CN(CCN1)c2ccc3ccccc3n2

InChI

1S/C13H15N3.C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

QYJJDHZHSCTBII-BTJKTKAUSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Related Categories

Bioactive Small Molecules

Application

Quipazine maleate salt has been used as a serotonin receptor agonist to study its effects on mouse models with spinal cord injury. It has also been used as a serotonin receptor agonist to study its effects on the locomotion of zebrafish.

Biochem/physiol Actions

Quipazine belongs to the class of psychedelics and acts as a serotonin/5-hydroxytryptamine-2A/C receptor agonist. It also acts as an inhibitor of prolactin.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Identification of drug-induced hyper- or hypoprolactinemia in the female rat based on general and reproductive toxicity study parameters.

Sabine Rehm et al.

Birth defects research. Part B, Developmental and reproductive toxicology, 80(3), 253-257 (2007-06-16)

Observations associated with drug-induced hyper- or hypoprolactinemia in rat toxicology studies may be similar and include increased ovarian weight due to increased presence of corpora lutea. Hyperprolactinemia may be distinguished if mammary gland hyperplasia with secretion and/or vaginal mucification is

Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

Elena Morelli et al.

Journal of medicinal chemistry, 52(11), 3548-3562 (2009-05-12)

The synthesis and the biological characterization of novel highly selective pyrroloquinoxaline 5-HT(3) receptor (5-HT(3)R) ligands are described. In functional and in vivo biological studies the novel quinoxalines modulated cardiac parameters by direct interaction with myocardial 5-HT(3)Rs. The potent 5-HT(3)R ligands

Pharmacological characterizations of recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes coupled to adenylate cyclase inhibition in clonal cell lines: apparent differences in drug intrinsic efficacies between human 5-HT1D subtypes.

J M Zgombick et al.

Naunyn-Schmiedeberg's archives of pharmacology, 354(3), 226-236 (1996-08-01)

Recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes were stably expressed in NIH-3T3 fibroblasts (1D alpha cell line) and Y-1 adrenocortical tumor cells (1D beta cell line), respectively, for pharmacological evaluations of serotonergic compounds to inhibit forskolin-stimulated cAMP accumulation

Involvement of Serotonin in crayfish hematopoiesis.

Chadanat Noonin

Developmental and comparative immunology, 86, 189-195 (2018-05-21)

Serotonin (5-HT) is a conserved monoamine neurotransmitter that has several physiological functions both in vertebrates and invertebrates. In addition to its well-known function in the central nervous system, 5-HT also participates in peripheral system. However, in crustaceans, the knowledge about

Afferent inputs to mid- and lower-lumbar spinal segments are necessary for stepping in spinal cats.

Jonathan A Norton et al.

Annals of the New York Academy of Sciences, 1198, 10-20 (2010-06-12)

Afferent inputs are known to modulate the activity of locomotor central pattern generators, but their role in the generation of locomotor patterns remains uncertain. This study sought to investigate the importance of afferent input for producing bilateral, coordinated hindlimb stepping

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Global Trade Item Number

SKU	GTIN
Q1004-50MG	04061832084374
Q1004-250MG	04061836687694

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