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R134

Rilmenidine hemifumarate salt

solid

Synonym(s):

N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt, Oxaminozoline hemifumarate salt, Rilmenidene hemifumarate salt

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About This Item

Empirical Formula (Hill Notation):
C10H16N2O · 0.5C4H4O4
CAS Number:
207572-68-7
Molecular Weight:
238.28
NACRES:
NA.77
PubChem Substance ID:
24277752
UNSPSC Code:
12352200
MDL number:
MFCD09878261
Form:
solid
Quality level:
100
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form

solid

Quality Level

100

color

white

solubility

DMSO: >10 mg/mL, H2O: insoluble

originator

Servier

SMILES string

OC(=O)\C=C\C(O)=O.C1CN=C(NC(C2CC2)C3CC3)O1.C4CN=C(NC(C5CC5)C6CC6)O4

InChI

1S/2C10H16N2O.C4H4O4/c2*1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10;5-3(6)1-2-4(7)8/h2*7-9H,1-6H2,(H,11,12);1-2H,(H,5,6)(H,7,8)/b;;2-1+

InChI key

LZFATBMLSYHRTC-WXXKFALUSA-N

Gene Information

human ... NISCH(11188)

Biochem/physiol Actions

Selective I1 imidazoline receptor agonist.

Features and Benefits

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Servier. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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Certificates of Analysis (COA)

Lot/Batch Number
0000542584
0000542585
0000504215
0000542585
0000542584

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Related Content

K Takada et al.
British journal of pharmacology, 120(8), 1575-1581 (1997-04-01)
1. To elucidate the possible involvement of pertussis toxin (PTX)-sensitive G proteins in the post receptor mechanism of alpha 2-adrenoceptors and imidazoline receptors, we examined the effect of pretreatment of the central nervous system with PTX on the antidysrhythmic effect
M A Ozog et al.
Journal of neurochemistry, 71(4), 1429-1435 (1998-09-29)
Rilmenidine, a ligand for imidazoline and alpha2-adrenergic receptors, is neuroprotective following focal cerebral ischemia. We investigated the effects of rilmenidine on cytosolic free Ca2+ concentration ([Ca2+]i) in rat astrocytes. Rilmenidine caused concentration-dependent elevation of [Ca2+]i, consisting of a transient increase
C K Chan et al.
The Journal of pharmacology and experimental therapeutics, 276(2), 411-420 (1996-02-01)
The present study in conscious rabbits with intracisternal (i.c.) catheters sought to determine the relative contribution of the I1 subtype of imidazoline receptors (IR) and alpha 2 adrenoceptors to the hypotensive effects of rilmenidine, clonidine and moxonidine with an I1-IR/alpha
View All Related Papers

Global Trade Item Number

SKUGTIN
R134-25MG04061832093178
R134-5MG04061832093185