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Merck
CN

R2530

Ropinirole hydrochloride

≥98% (HPLC), D2 and D3 dopamine receptor agonist, powder

Synonym(s):

SKF 101468 hydrochloride, 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H24N2O · HCl
CAS Number:
91374-20-8
Molecular Weight:
296.84
UNSPSC Code:
12352200
PubChem Substance ID:
329824018
NACRES:
NA.77
MDL number:
MFCD01754173

Key Documents

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Product Name

Ropinirole hydrochloride, powder, ≥98% (HPLC)

SMILES string

Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12

InChI key

XDXHAEQXIBQUEZ-UHFFFAOYSA-N

InChI

1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

light yellow

solubility

H2O: >10 mg/mL

originator

GlaxoSmithKline

Quality Level

100

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815)

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Biochem/physiol Actions

An agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.
Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.
Selective D2 dopamine receptor agonist, antiparkinsonian

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000402354
0000402354
0000219161
0000219161
0000184635

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Carlo Tessa et al.
Parkinsonism & related disorders, 19(2), 265-268 (2012-08-21)
Previous fMRI studies indicated a relationship between changes of the cortical activation pattern and disease severity in Parkinson's disease (PD). Early diagnosis of Parkinson's disease offers the opportunity to evaluate the putative neuroprotective and disease-modifying effects of drugs at a
Sébastien Duband et al.
Journal of forensic and legal medicine, 19(7), 422-425 (2012-08-28)
Ropinirole, a specific non-ergoline dopamine D2-receptor agonist, belongs to the drugs applied in treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) and acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D3. Therapeutic
Spontaneous unwelcome orgasms due to pramipexole and ropinirole.
Oliver Kaut et al.
Movement disorders : official journal of the Movement Disorder Society, 27(10), 1327-1328 (2012-08-21)
Ropinirole for the treatment of early Parkinson's disease
Adler C H, et al.
Neurology, 49(2), 393-399 (1997)
Ropinirole as an effective adjunctive treatment for clozapine-resistant negative symptoms in simple schizophrenia: a case report.
Panayiota G Michalopoulou et al.
Journal of clinical psychopharmacology, 32(5), 719-720 (2012-08-29)
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