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Merck
CN

R4903

Anti-hnRNP-L antibody, Mouse monoclonal

clone 4D11, purified from hybridoma cell culture

Synonym(s):

Anti-Heterogeneous Nuclear Ribonucleoprotein-L

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD03845440

Key Documents

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Product Name

Anti-hnRNP-L antibody, Mouse monoclonal, clone 4D11, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

4D11, monoclonal

form

buffered aqueous solution

mol wt

antigen ~68 kDa

species reactivity

bovine, newt, chicken, human, monkey, mouse

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.25-0.5 μg/mL using total cell extract of MDBK cells

isotype

IgG1

UniProt accession no.

P14866

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... HNRNPL(3191)
mouse ... Hnrnpl(15388)

Related Categories

Application

Anti-hnRNP-L antibody has been used in
  • immunoblotting
  • enzyme linked immunosorbent assay (ELISA)
  • immunoprecipitation
  • immunocytochemistry
  • western blotting

Biochem/physiol Actions

Heterogeneous nuclear ribonucleoproteins-L (hnRNP-L) is involved in splicing regulations, internal translation initiation of hepatitis C virus (HCV), stability of the human vascular endothelial growth factor (VEGF) mRNA under hypoxic growth conditions, and intron independent mRNA export.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-hnRNP-L (mouse IgG1 isotype) is derived from the 4D11 hybridoma produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALA/c mice immunized with hnRNP proteins and purified by affinity chromatography on ssDNA-agarose. RNA polymerase II transcripts in the nucleus are in complex with several proteins called heterogeneous nuclear ribonucleoproteins (hnRNPs). hnRNPs consist of protein groups named A to U and many of these protein groups consist of more than one isoform. Group L and M are one of the most abundant groups of proteins.

Immunogen

hnRNP proteins.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000445889
0000445889
0000367300
0000367300
0000265904

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Auto-and cross-regulation of the hnRNP L proteins by alternative splicing
RossbachO, et al.
Molecular and cellular biology, 29(6), 1442-1451 (2009)
Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L
Shih S C and Claffey K P
The Journal of Biological Chemistry, 274(3), 1359-1365 (1999)
HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression.
Liu X and Mertz J E
Genes & Development, 9(14), 1766-1780 (1995)
Ana Rita Agra Almeida Quadros et al.
Acta neuropathologica, 147(1), 9-9 (2024-01-04)
Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up to 50% of patients with frontotemporal dementia (FTD) and Alzheimer's disease. In Alzheimer's disease, TDP-43 pathology
Heterogeneous nuclear ribonucleoprotein L interacts with the 3? border of the internal ribosomal entry site of hepatitis C virus
Hahm B, et al.
Journal of Virology, 72(11), 8782-8788 (1998)
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