R5278
Anti-RAGE (Receptor for Advanced Glycation Endproducts) antibody produced in rabbit
affinity isolated antibody
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
15
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, rat
technique(s)
immunohistochemistry: 1-2 μg/mL using transgenic mouse retina, western blot: 1 μg/mL using using mouse lung extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AGER(177)
mouse ... Ager(11596)
rat ... Ager(81722)
Related Categories
General description
Receptor for advanced glycation end products (RAGE), also known as advanced glycosylation end-product specific receptor (AGER) is encoded by the gene mapped to human chromosome 6p21. The encoded protein is a member of the immunoglobulin superfamily of cell surface molecules.
Immunogen
synthetic peptide corresponding to amino acid residues 362-380 from rat RAGE. This sequence is 100% conserved in mouse and 70% conserved in human.
Application
Anti-RAGE (Receptor for Advanced Glycation Endproducts) antibody produced in rabbit has been used in western blot and flow cytometry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
The soluble form of receptor for advanced glycation end products (RAGE) has a function in the Wnt pathway. RAGE has a role in the development of inflammatory and cellular damage, as well as cellular toxicity. It has been associated with diabetic atherosclerosis. AGER/RAGE also modulates cell proliferation, differentiation and apoptosis.{93
Physical form
Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Association of RAGE gene Gly82Ser polymorphism with coronary artery disease and ischemic stroke
Ma W Q, et al.
Medicine, 95(49) (2016)
Susmita Barman et al.
Chemico-biological interactions, 307, 37-50 (2019-04-23)
Zinc depletion during diabetes postulates a role for zinc nutrition in the management of associated complications. The present study evaluated zinc supplementation for countering the compromised intestinal integrity through moderation of oxidative stress and suppression of stress-stimulated inflammatory proliferation in
Association of Polymorphisms of the Receptor for Advanced Glycation Endproducts Gene with Schizophrenia in a Han Chinese Population
Fu J, et al.
BioMed Research International (2017)
Is there a role for high mobility group box 1 and the receptor for advanced glycation end products in the genesis of long-term cognitive impairment in sepsis survivors?
Felipe Dal-Pizzol et al.
Molecular medicine (Cambridge, Mass.), 18, 1357-1358 (2012-11-02)
Circulating sRAGE in the diagnosis of osteolytic bone metastasis.
Galliera E
Journal of Biological Regulators and Homeostatic Agents, 30(4), 1203-1208 (2016)
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Instructions
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