S179
R(+)-SKF-81297 hydrobromide
≥98% (HPLC), Dopamine receptor agonist, solid
Synonym(s):
R-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
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About This Item
Empirical Formula (Hill Notation):
C16H16ClNO2 · HBr
CAS Number:
Molecular Weight:
370.67
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light
Product Name
R(+)-SKF-81297 hydrobromide, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
optical activity
[α]22/D +15.14°, c = 0.52 in DMF(lit.)
storage condition
desiccated, protect from light
color
white to off-white
solubility
H2O: 6 mg/mL, DMSO: soluble
SMILES string
Br[H].Oc1cc2[C@H](CNCCc2c(Cl)c1O)c3ccccc3
InChI
1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H/t13-;/m1./s1
InChI key
RMIJGBMRNYUZRG-BTQNPOSSSA-N
Application
R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist:
- to test it effect on the spike firing in rat retinal ganglion cells
- in human embryonic kidney (HEK) 293T cells
- to test its inhibitory effect in microglial cells
Biochem/physiol Actions
SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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