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S179

R(+)-SKF-81297 hydrobromide

≥98% (HPLC), Dopamine receptor agonist, solid

Synonym(s):

R-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C16H16ClNO2 · HBr
CAS Number:
253446-15-0
Molecular Weight:
370.67
UNSPSC Code:
12352200
PubChem Substance ID:
24899496
NACRES:
NA.77
MDL number:
MFCD00671792
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light
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Product Name

R(+)-SKF-81297 hydrobromide, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]22/D +15.14°, c = 0.52 in DMF(lit.)

storage condition

desiccated, protect from light

color

white to off-white

solubility

H2O: 6 mg/mL, DMSO: soluble

SMILES string

Br[H].Oc1cc2[C@H](CNCCc2c(Cl)c1O)c3ccccc3

InChI

1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H/t13-;/m1./s1

InChI key

RMIJGBMRNYUZRG-BTQNPOSSSA-N

Application

R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist:
  • to test it effect on the spike firing in rat retinal ganglion cells
  • in human embryonic kidney (HEK) 293T cells
  • to test its inhibitory effect in microglial cells

Biochem/physiol Actions

SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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