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S5068

Salmeterol xinafoate

≥98% (HPLC), β2 adrenoceptor agonist, solid

Synonym(s):

(±) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol xinafoate, GR 33343X xinafoate

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About This Item

Empirical Formula (Hill Notation):
C25H37NO4 · C11H8O3
CAS Number:
94749-08-3
Molecular Weight:
603.75
UNSPSC Code:
12352200
PubChem Substance ID:
24278713
NACRES:
NA.77
MDL number:
MFCD00897708
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
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Product Name

Salmeterol xinafoate, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

H2O: slightly soluble, ethanol: slightly soluble, methanol: freely soluble

originator

GlaxoSmithKline

SMILES string

OC(=O)c1ccc2ccccc2c1O.OCc3cc(ccc3O)C(O)CNCCCCCCOCCCCc4ccccc4

InChI

1S/C25H37NO4.C11H8O3/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21;12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2;1-6,12H,(H,13,14)

InChI key

XTZNCVSCVHTPAI-UHFFFAOYSA-N

Gene Information

human ... ADRB2(154)

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Application

Salmeterol xinafoate was used as conjugate with human serum albumin to study the immune responses in rabbits.7

Biochem/physiol Actions

β2-adrenoceptor agonist.
Salmeterol xinafoate is a β2 adrenoceptor agonist with longer lasting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles, stabilizes mast cells and regulates the release of histamine. Salmetrol is particularly effective in treatment of mild asthma, chronic obstructive pulmonary disorder.5,6

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV6098
MKCH0814
MKBV7573V
MKBQ2324V
SLBC3795V

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Claus Vogelmeier et al.
Respiratory medicine, 107(1), 75-83 (2012-10-30)
The objective of this study was to investigate the effect of tiotropium compared with salmeterol on exacerbations in patients with moderate (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage II) chronic obstructive pulmonary disease (COPD) and those naïve to
Marc Decramer et al.
Respiratory medicine, 107(2), 223-232 (2012-12-12)
Indacaterol is a once-daily, long-acting β(2)-agonist bronchodilator that improves dyspnoea and health status in patients with moderate-to-severe COPD. While its bronchodilator effects have been shown to be maintained in different patient subgroups, effects on clinical outcomes in certain subgroups are
Finney, P.A., et al.
British Journal of Pharmacology, 132, 1267-1270 (2001)
Terence L Fodey et al.
Analytica chimica acta, 637(1-2), 328-332 (2009-03-17)
Haptens are low molecular weight compounds that are non-immunogenic and so must be conjugated to carrier molecules to elicit an immune response. Doses of 50-1000 microg protein conjugate have been suggested for immunisation of rabbits with hapten-protein immunogens. Although larger
Basak Isin et al.
PloS one, 7(12), e50186-e50186 (2013-01-10)
Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that the difference between the effects of various agonists and antagonists cannot be explained by single structures alone, but rather that the conformational ensembles of the proteins need to
View All Related Papers

Global Trade Item Number

SKUGTIN
S5068-10MG04061836937126
S5068-50MG04061832093581

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