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Merck
CN

S8701

Sigma-Aldrich

SFLLR-NH2 trifluoroacetate salt

≥95% (HPLC), powder

Synonym(s):

L-Seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-Arginine amide trifluoroacetate salt, Ser-Phe-Leu-Leu-Arg-amide trifluoroacetate salt, Thrombin Receptor Activator for Peptide 5 (TRAP-5) trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C30H51N9O6 · xC2HF3O2
CAS Number:
1313730-13-0
Molecular Weight:
633.78 (free base basis)
MDL number:
MFCD18782167
UNSPSC Code:
12352200
PubChem Substance ID:
329824608
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to off-white

solubility

H2O: ≥2 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

InChI

1S/C30H51N9O6.C2HF3O2/c1-17(2)13-22(27(43)36-21(25(32)41)11-8-12-35-30(33)34)38-28(44)23(14-18(3)4)39-29(45)24(37-26(42)20(31)16-40)15-19-9-6-5-7-10-19;3-2(4,5)1(6)7/h5-7,9-10,17-18,20-24,40H,8,11-16,31H2,1-4H3,(H2,32,41)(H,36,43)(H,37,42)(H,38,44)(H,39,45)(H4,33,34,35);(H,6,7)/t20-,21-,22-,23-,24-;/m0./s1

InChI key

UUNMFWMQJXBTAA-VHIJBDTGSA-N

Related Categories

Application

SFLLR-NH2 trifluoroacetate salt may be used in cell signaling and immunology studies.

Biochem/physiol Actions

SFLLR-NH2 is a PAR-1 (Protease-Activated Receptor) selective activating peptide, also known as Thrombin Receptor Activating Peptide 5 (TRAP-5). Protease-activated receptors (PARs) are present on various organs including, platelets, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing and proliferation of astrocytes.
SFLLR-NH2 is a PAR-1 agonist peptide, Thrombin Receptor Activating Peptide (TRAP).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000127059
0000127059
0000126212
086M4707V
044M4750V

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