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Merck
CN

S9317

PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt

≥97% (HPLC), proteinase-activated receptor 2 peptide agonist, solid

Synonym(s):

PAR2-AP, SLIGRL−NH2, Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C29H56O7N10 · C2HF3O2
Molecular Weight:
770.84
UNSPSC Code:
51111800
PubChem Substance ID:
329824620
NACRES:
NA.32
MDL number:
MFCD03093421

Key Documents

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Product Name

PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt, ≥97% (HPLC)

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O

InChI key

SGPMJRPYYIJZPC-JYAZKYGWSA-N

InChI

1S/C29H56N10O7/c1-7-17(6)23(39-27(45)21(12-16(4)5)38-25(43)18(30)14-40)28(46)35-13-22(41)36-19(9-8-10-34-29(32)33)26(44)37-20(24(31)42)11-15(2)3/h15-21,23,40H,7-14,30H2,1-6H3,(H2,31,42)(H,35,46)(H,36,41)(H,37,44)(H,38,43)(H,39,45)(H4,32,33,34)/t17-,18-,19-,20-,21-,23-/m0/s1

assay

≥97% (HPLC)

form

solid

storage temp.

−20°C

Quality Level

200

Related Categories

Application

PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt has been used as a proteinase-activated receptor 2 (PAR-2) agonist to induce the expression of Hh and Hippo genes in Hek293A cells.

Biochem/physiol Actions

Selective proteinase-activated receptor 2 (PAR2) peptide agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
0000451697
0000451697
0000362533
0000362533
0000231165

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The majority of the severe vascular complications in fibrosis are a consequence of a deregulated activity of mediators controlling vasomotor tone. One of the most important of these mediators is endothelin-1 (ET-1). Here, we have investigated the role of proteinase-activated
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The production of soluble fms-like tyrosine kinase 1 (sFLT1) by exogenous chymotrypsin in trophoblast cells through protease-activated receptor (PAR) 2 was investigated to identify the role of a chymotrypsin-like serine protease in preeclampsia (PE) pathogenesis. We evaluated the expression of
William G Darby et al.
Pharmacological research, 133, 152-159 (2018-05-23)
The aim of this study was to better understand the role of TRPV4 in the regulation of blood vessel dilatation by blood flow and activation of GPCRs. Using pressure myography, the dilator responses to the TRPV4 agonist GSK1016790A and to
Tomoki Fukuyama et al.
BMC pharmacology & toxicology, 19(1), 37-37 (2018-07-05)
Topical administration of PR022, 0.05% hypochlorous acid (HOCl) in gel has been demonstrated to be beneficial in a chronic murine atopic dermatitis model. In a follow up study we tested a higher concentration (0.1%) of PR022 HOCl gel in comparison
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