SAB1300152
Anti-MOZ/MYST3 (N-term) antibody produced in rabbit
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
Synonym(s):
Anti-Histone acetyltransferase MYST3, Anti-MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3, Anti-MYST protein 3, Monocytic leukemia zinc finger protein, Runt-related transcription factor-binding protein 2
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
saturated ammonium sulfate (SAS) precipitated
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: 1:50-1:100, indirect ELISA: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MYST3(7994)
General description
MOZ (monocytic leukemia zinc finger protein) is also known as lysine acetyltransferase 6 (KAT6A) and belongs to the MYST (MOZ, YBF2/SAS3, SAS2 and TIP60) family. The KAT6 gene is mapped to human chromosomes 8p11.21. The structure of KAT6 is evolutionarily conserved in organisms ranging from yeast to mammals. The encoded protein contains a nuclear localization domain (including H15), a histone-acetyltransferase domain (HAT), an acidic glutamate/aspartate-rich region, a double-plant homeodomain finger that interacts with acetylated histone H3 tails (PHD 1 and 2) and a serine and methionine-rich region containing a transactivation domain. In humans, the gene is broadly expressed in different tissues, strongly in the brain and low in the heart.
MOZ/MYST3 is a histone acetyltransferase which may act as a transcriptional coactivator for RUNX1 and RUNX2.
Immunogen
MOZ/MYST3 (NP_001092882, 72-108)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MYST3.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MYST3.
Biochem/physiol Actions
KAT6A (lysine acetyltransferase 6A) is a histone acetyltransferase. It is a transcriptional co-activator. It acetylates histone H3 at K14 and K9 and H4 at K5, K8, K12 and K16 in vitro. KAT6A is associated with the regulation of cell cycle and stem cell homeostasis. In acute myeloid leukemia the involvement of KAT6A along with CREB binding protein has been observed. KAT6A acts as an oncogene. Mutations and abnormal regulation in KAT6 gene is associated with solid tumors and developmental disorders in human. It serves as a key epigenetic regulator of hematopoiesis. Mutations in the gene lead to abnormal acetylation of K9 and K18 of histone3 as well as changes in the P53 signaling. Therefore, affecting multiple cellular processes and controlling disease conditions.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Emma Tham et al.
American journal of human genetics, 96(3), 507-513 (2015-03-03)
Through a multi-center collaboration study, we here report six individuals from five unrelated families, with mutations in KAT6A/MOZ detected by whole-exome sequencing. All five different de novo heterozygous truncating mutations were located in the C-terminal transactivation domain of KAT6A: NM_001099412.1:
Valerie A Arboleda et al.
American journal of human genetics, 96(3), 498-506 (2015-03-03)
Chromatin remodeling through histone acetyltransferase (HAT) and histone deactylase (HDAC) enzymes affects fundamental cellular processes including the cell-cycle, cell differentiation, metabolism, and apoptosis. Nonsense mutations in genes that are involved in histone acetylation and deacetylation result in multiple congenital anomalies
Xiaozhe Xiong et al.
Nature chemical biology, 12(12), 1111-1118 (2016-10-25)
Recognition of histone covalent modifications by 'reader' modules constitutes a major mechanism for epigenetic regulation. A recent upsurge of newly discovered histone lysine acylations, such as crotonylation (Kcr), butyrylation (Kbu), and propionylation (Kpr), greatly expands the coding potential of histone
Fu Huang et al.
Molecular and cellular biology, 36(14), 1900-1907 (2016-05-18)
The lysine acetyltransferase 6 (KAT6) histone acetyltransferase (HAT) complexes are highly conserved from yeast to higher organisms. They acetylate histone H3 and other nonhistone substrates and are involved in cell cycle regulation and stem cell maintenance. In addition, the human
Brittany Turner-Ivey et al.
Neoplasia (New York, N.Y.), 16(8), 644-655 (2014-09-16)
The chromosome 8p11-p12 amplicon is present in 12% to 15% of breast cancers, resulting in an increase in copy number and expression of several chromatin modifiers in these tumors, including KAT6A. Previous analyses in SUM-52 breast cancer cells showed amplification
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