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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

saturated ammonium sulfate (SAS) precipitated

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

Drosophila

technique(s)

indirect ELISA: 1:1000
western blot: 1:100-1:500

NCBI accession no.

NP_730600

UniProt accession no.

Q7KTX7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

Drosophila melanogaster ... Park(40336)

General description

Parkin gene is located on Drosophila melanogaster chromosome 78C2. This gene codes for the enzyme E3 ubiquitin ligase, which localizes in the cytosol.
Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.

Immunogen

PARKIN (NP_730600, )
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Drosophila Parkin.

Application

Anti-Drosophila Parkin (C-term) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Mutation in the parkin gene leads to Parkinson′s disease. The encoded protein is involved in quality control mechanism for the disposal of abnormal mitochondria, thereby maintaining lifespan and controlling locomotion. Parkin along with PTEN-induced putative kinase 1 (PINK1) targets mitochondria for its degradation through autophagy.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
020M2225

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