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SAB1305652

Sigma-Aldrich

ANTI-CD11B(N-TERMINAL) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
CD11 antigen-like family member B, CD11B, CR3A, ITGAM, Integrin alpha-M
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

127179 Da

species reactivity

human

technique(s)

flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000

NCBI accession no.

NP_000623.2

UniProt accession no.

P11215

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ITGAM(3684)

Related Categories

General description

Cluster of differentiation 11b (CD11b), also known as integrin subunit α M (ITGAM), is encoded by the gene mapped to human chromosome 16p11.2. It belongs to the integrin α chain family. CD11b is expressed by a variety of myeloid cell types, such as dendritic cells, macrophages, monocytes and neutrophils.

Biochem/physiol Actions

Cluster of differentiation 11b (CD11b) acts as a receptor for complement component C3 degradation product, iC3b. CD11b interacts with β2 chain (ITGB2) to form a leukocyte integrin (MAC-1 or complement receptor 3 (CR3)), which in turn plays a crucial role in adherence of neutrophils and monocytes to stimulated endothelium. Mutation in the gene increases the risk of susceptibility to systemic lupus erythematosus (SLE) and acute inflammatory demyelinating polyradiculoneuropathy (AIDP).

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
Harley JB, et al.
Nature Genetics (2008)
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
Nath SK, et al.
Nature Genetics (2008)
The pathogenic relevance of aM-integrin in Guillain-Barre syndrome.
Acta Neuropathologica (2016)
Association of Systemic Lupus Erythematosus with C8orf13?BLK and ITGAM?ITGAX
Geoffrey Hom,et al.
New. J. Chem. (2008)

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