SAB1404503
Monoclonal Anti-TYMS antibody produced in mouse
clone 2B2, purified immunoglobulin, buffered aqueous solution
Synonym(s):
HsT422, MGC88736, TMS, TS, TSase
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
2B2, monoclonal
Application:
ELISA (i), IHC (p), IP, WB
Citations:
4
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2B2, monoclonal
form
buffered aqueous solution
mol wt
antigen ~37.11 kDa
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TYMS(7298)
General description
The gene encoding thymidylate synthetase (TYMS) is localized on human chromosome 18p11.32.
Immunogen
TYMS (AAH13919, 111 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSC
Sequence
ANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSC
Biochem/physiol Actions
Thymidylate synthetase (TYMS) has a role in DNA replication and thymidylate biosynthesis. It is also involved in cell survival and proliferation. TYMS takes part in folate metabolism. The protein methylates deoxyuridylate to deoxythymidylate.
Physical form
Solution in phosphate buffered saline, pH 7.4
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
Wang T, et al
Proceedings of the National Academy of Sciences of the USA, 101(9), 3089-3094 (2004)
Thymidylate synthase gene polymorphisms as important contributors affecting hepatocellular carcinoma prognosis.
Wang X, et al.
Clinics and Research in Hepatology and Gastroenterology, 4193), 319-326 (2017)
Thymidylate synthase polymorphisms and risk of lung cancer among the Jordanian population: a case control study.
Qasem W A, et al.
Asian Pacific Journal of Cancer Prevention, 16, 8287-8292 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB1404503-100UG | 04061831658132 |