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SAB2500221

Anti-CDKN2A (Isoform 1)/P16INK4A antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Cyclin-dependent kinase inhibitor 2A, Anti-HGNC:1787, Anti-p16INK4a

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00282397
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
indirect ELISA
western blot
Species reactivity:
human
Citations:
3
Technique(s):
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
P42771

Key Documents

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Product Name

Anti-CDKN2A (Isoform 1)/P16INK4A antibody produced in goat, affinity isolated antibody, buffered aqueous solution

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P42771

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CDKN2A(1029)

Related Categories

Biochem/physiol Actions

Cyclin dependent kinase inhibitor 2A (CDKN2A), also known as P16-INK4A, arrests cell cycle progression by inhibiting S-phase and promotes apoptosis. The encoded protein has anti-proliferative biological activity, and is implicated in the retinoblastoma (Rb) protein pathway. P16-INK4A acts as a tumor suppressor and plays a vital role in ageing and cellular senescence. Increased expression of this protein might lead to various types of high grade cancers. P16-INK4A also facilitates cell invasion and angiogenesis. Bronchial lavage P16INK4A promoter methylation might function as a potential biomarker for diagnosis of lung cancer.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Cyclin dependent kinase inhibitor 2A (CDKN2A), also known as P16-INK4A, belongs to the Ink4 (inhibitor of CDK4) family of CDK inhibitors. It is encoded by the gene mapped to human chromosome 9p21 within the INK4a/ alternate reading frame (ARF) locus. Human P16-INK4A is localized in both nucleus and cytoplasm, and its expression increases with ageing in skin and kidney tissues.

Immunogen

Peptide with sequence C-HARIDAAEGPSDIPD from the C Terminus of the protein sequence according to NP_000068.1.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
7094P1

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Find documentation for the products that you have recently purchased in the Document Library.

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Bronchial lavage P 16INK4A gene promoter methylation and lung cancer diagnosis: A meta-analysis.
Yifan D
Indian Journal of Cancer (2015)
Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma.
Koenig A
Veterinary Pathology (2002)
p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.
Romagosa C
Oncogene (2011)

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