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Merck
CN

SAB2500307

Anti-DGAT1 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ACAT related gene product 1, Anti-ARGP1, Anti-Acyl coenzyme A:cholesterol acyltransferase related gene 1, Anti-DGAT, Anti-Diacylglycerol O-acyltransferase homolog 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, canine, mouse

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

O75907

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DGAT1(8694)

Related Categories

General description

Diacylglycerol O-acyltransferase 1 (DGAT1) is a 500kDa, hydrophobic protein, which is highly expressed in the skin, mammary gland, adipose tissue, small intestine and testis. The gene encoding it is localized on human chromosome 8q24.3.

Immunogen

Peptide with sequence C-QNSMKPFKDMDYS from the internal region of the protein sequence according to NP_036211.1.

Application

Anti-DGAT1 antibody produced in goat has been used in Western blotting.

Biochem/physiol Actions

Diacylglycerol O-acyltransferase 1 (DGAT1) has a role in the biosynthesis of triglycerides. Mutations in the gene have been linked to congenital diarrhea and protein-losing enteropathy. DGAT1 is also associated with metabolic disorders like diabetes and obesity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
7575S2G2
7575P1

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Exclusion of the acyl CoA:diacylglycerol acyltransferase 1 gene (DGAT1) as a candidate for a fatty acid composition QTL on porcine chromosome 4
A. Mercade
Journal of Animal Breeding and Genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie (2005)
Prolonged silencing of diacylglycerol acyltransferase-1 induces a dedifferentiated phenotype in human liver cells.
Chang S
Journal of Cellular and Molecular Medicine (2016)
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
Chi-Liang
Journal of Lipid Research (2005)
Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.
Gluchowski NL
Journal of Lipid Research (2017)

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