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Merck
CN

SAB4200529

Anti-HMGCR (internal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-3-hydroxy-3-methylglutaryl-CoA reductase, LDLCQ3

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-HMGCR (internal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~100 kDa

species reactivity

human, mouse, rat

concentration

~1.0 mg/mL

technique(s)

western blot: 1.5-3.0 μg/mL using extracts of mevastatin-treated HepG2 cells, and of mouse and rat liver microsomes.

UniProt accession no.

P04035

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... HMGCR(3156)

Biochem/physiol Actions

3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) plays a major role in mevalonate biosynthesis, which is a rate limiting step of cholesterol biosynthesis in the liver. Additionally, it also plays a key role in various biological process such as, embryogenesis and cancer. Elevated expression of the gene is associated with the development of gastric cancer(GC) and glioblastoma cells. Thus, HMGCR can be considered as a potent therapeutic target for GC and glioblastoma.
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) acts as the rate-limiting step in cholesterol synthesis. Polymorphism in HMGCR results in late-onset Alzheimer′s disease. It induces the growth and migration of the cancer cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a transmembrane glycoprotein, encoded by the gene mapped to human chromosome 5q13.3-q14. HMGCR has a molecular mass of 97kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues.
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) codes for a part of the statin-binding domain of the enzyme. This gene is located on human chromosome 5q13. HMGCR has a molecular mass of 97kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues.

Immunogen

synthetic peptide corresponding to an internal sequence of human HMGCR, conjugated to KLH. The corresponding sequence is identical in human HMGCR isoform 2 and highly conserved in mouse (89% identity) and in rat (83% identity) HMGCR.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000411446
0000411446
0000404576
0000404576
0000242794

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Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13
Sundaresan S
Somatic Cell and Molecular Genetics, 15, 465-469 (1989)
HMGCR positively regulated the growth and migration of glioblastoma cells.
Qiu Z
Gene, 576, 22-27 (2016)
Hmgcr in the Corpus Allatum Controls Sexual Dimorphism of Locomotor Activity and Body Size via the Insulin Pathway in Drosophila
Belgacem YH and Martin JR
PLoS ONE, 2 (2007)
Xiaojia Chen et al.
Heliyon, 9(12), e22785-e22785 (2023-12-13)
Methyl protodioscin (MPD) is the main component of total diosgenin, which was reported to reduce cholesterol and triglyceride levels potentially. This study aimed to investigate the beneficial effects of MPD against lipid disorder in hyperlipidemic gerbils induced by a high-fat
HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells.
Chushi L
Gene, 587, 42-47 (2016)
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