Skip to Content
Merck
CN

SAB4200764

Anti-Dystrophin Antibody

mouse monoclonal, MANDYS8

Synonym(s):

Anti-DMD

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Clone:
MANDYS8, monoclonal
Species reactivity:
porcine, rabbit, mouse, rat, human
Application:
immunoblotting
immunohistochemistry
Technique(s):
immunoblotting: suitable
immunohistochemistry: 5-10 μg/mL using acetone fixed rat tongue frozen sections
Citations:
3
Uniprot accession no.:
P11532

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Anti-Dystrophin antibody, Mouse monoclonal, clone MANDYS8, purified from hybridoma cell culture

biological source

mouse

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

MANDYS8, monoclonal

form

buffered aqueous solution

mol wt

~427 kDa

species reactivity

porcine, rabbit, mouse, rat, human

enhanced validation

independent
Learn more about Antibody Enhanced Validation

concentration

~1.0 mg/mL

technique(s)

immunoblotting: suitable
immunohistochemistry: 5-10 μg/mL using acetone fixed rat tongue frozen sections

isotype

IgG2b

UniProt accession no.

P11532

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... DMD(1756)

Related Categories

Immunogen

recombinant human dystrophin

Other Notes

This product is for R&D use only, not for drug, household, or other uses.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative.

Application

Anti-Dystrophin antibody, Mouse monoclonal has been used in immunoblotting and immunohistochemistry.

Biochem/physiol Actions

Anti-Dystrophin antibody, Mouse monoclonal specifically recognizes an epitope located on the rod domain of the human dystrophin molecule.
Dystrophin is known to prevent muscle fibre injury due to contraction.

General description

Anti-Dystrophin antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the MANDYS8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with fragment of recombinant human dystrophin. Dystrophin is a 427 kD protein which joins the actin cytoskeleton to laminin. It possesses multiple domains and is localized to the extracellular matrix. Dystrophin contains NH2-terminal domain for actin binding. The C-terminal domain interacts with dystrophin associated protein (DAP).
Dystrophin is a rod-shaped cytoskeletal protein located to the periphery (plasma membrane) of normal striated muscle fibers.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000463769
0000463769
0000405454
0000405454
0000272519

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Applications of CRISPR technologies in research and beyond
Barrangou R and Doudna JA
Nature Biotechnology, 34(9), 933-933 (2016)
Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria
Strauss JA, et al.
Physiological Reports, 4(1), e12662-e12662 (2016)
Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain
Crawford GF, et al.
The Journal of Cell Biology, 150(6), 1399-1410 (2000)

Related Content

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service