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SAB4300458

Anti-RPS6KA5 (Ab-376) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MGC1911 antibody produced in rabbit, Anti-MSK1 antibody produced in rabbit, Anti-MSPK1 antibody produced in rabbit, Anti-RLPK antibody produced in rabbit, Anti-ribosomal protein S6 kinase, 90kDa, polypeptide 5 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02686432
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human
Citations:
4
Technique(s):
western blot: 1:500-1:1000
Uniprot accession no.:
O75582

Key Documents

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Product Name

Anti-RPS6KA5 (Ab-376) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~90 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(G-Y-S-F-V)

NCBI accession no.

NP_004746.2

UniProt accession no.

O75582

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... RPS6KA5(9252)

Related Categories

Biochem/physiol Actions

RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) acts as a connector between extracellular signals and gene expression. It helps in the phosphorylation of chromatin protein histone H3 and high mobility group 14 (HMG14) . MSK1 plays a key role in the development of hormone-dependent breast cancer.

Features and Benefits

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General description

RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) is a nuclear serine/threonine protein kinase , that is located on human chromosome 14q32. It is a dual kinase domain protein.
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Immunogen

Peptide sequence around aa. 374-378 (G-Y-S-F-V), according to the protein RPS6KA5.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
871521198

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Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS
McCoy CE, et al.
The Biochemical Journal, 402(3), 491-501 (2007)
Activation of mitogen- and stress-activated kinase 1 is required for proliferation of breast cancer cells in response to estrogens or progestins
Reyes D, et al.
Oncogene, 33(12), 1570-1580 (2014)
Mitogen- and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun gene
Li B, et al.
BMC Cancer, 15:390 (2015)
Prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial duplication of 14q (14q31.3?q32.12) associated with abnormal maternal serum biochemistry
Chen CP, et al.
Taiwanese Journal of Obstetrics & Gynecology, 52(1), 125-128 (2013)

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