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Merck
CN

SAB4300609

Anti-FLT4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLT41 antibody produced in rabbit, Anti-LMPH1A antibody produced in rabbit, Anti-PCL antibody produced in rabbit, Anti-VEGFR3 antibody produced in rabbit, Anti-fms-related tyrosine kinase 4 antibody produced in rabbit

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About This Item

MDL number:
MFCD03097363
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~160 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(L-A-S-E-E)

NCBI accession no.

NP_002011.2

UniProt accession no.

P35916

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FLT4(2324)

Related Categories

General description

Fms related tyrosine kinase 4 (FLT4) is also known as vascular endothelial growth factor receptor 3 (VEGFR3). It is expressed in the blood and lymphatic endothelial cells during early development. The gene encoding FLT4 is localized on human chromosome 5q35.3.
Receptor for VEGFC. Has a tyrosine-protein kinase activity.

Immunogen

Peptide sequence around aa. 1279-1283 (L-A-S-E-E), according to the protein FLT4.

Application

Anti-FLT4 antibody produced in rabbit has been used in immunohistochemistry.

Biochem/physiol Actions

Fms related tyrosine kinase 4 (FLT4) has a role in lymphangiogenesis and angiogenesis. It acts as an activator in signaling pathways. Mutations in the gene encoding FLT4 have been linked to Milroy disease.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
871521410

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Two anti-angiogenic TKI-PET tracers, [11C]axitinib and [11C]nintedanib: Radiosynthesis, in vivo metabolism and initial biodistribution studies in rodents
Paul S, et al.
Nuclear Medicine and Biology null
A novel FLT4 Gene mutation and MR lymphangiography in a Chinese family with Milroy disease
Liu, N., et al.
Lymphology, 93-6 (2015)
Molecular controls of lymphatic VEGFR3 signaling
Deng, Yong et al.
Atherosclerosis: Treatment and Prevention (2014)

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