SAB4301339
Anti-phospho-4E-BP1 (pThr70) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
4EBP1, P/OKCL.6, PHAS-I
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
12 kDa
species reactivity
human
concentration
1.0 mg/mL
technique(s)
immunohistochemistry: 1:50-1:100
isotype
IgG
accession no.
NP_004086.1.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pThr70)
Gene Information
human ... EIF4EBP1(1978)
General description
The gene EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) is localized on human chromosome 8p12. It is a translation repressor that interacts with eukaryotic translation initiation factor 4E (eIF4E).
Immunogen
Peptide sequence around phosphorylation site of threonine70 (T-K-T(p)-P-P) derived from Human 4E-BP1.
Biochem/physiol Actions
EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) associates with eukaryotic translation initiation factor 4E (eIF4E), which is a multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNA. The interaction of the encoded binding protein with this complex inhibits translation. The phosphorylation of EIF4EBP1 in response to stimuli such as, UV irradiation and insulin signaling, results in dissociation of this factor from the eIF4E complex, leading to initiation of translation of mRNA. This protein participates in cell proliferation, apoptosis, invasion and metastasis. EIF4EBP1 functions as an effector molecule in mTOR (mammalian target of rapamycin complex 1) signaling pathway that regulates protein synthesis. It is found to be overexpressed in hepatocellular carcinoma tissues and serves as a potential prognostic and therapeutic target.
The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer.
Boylan MO, et al.
Breast Cancer Research, 272(28), 17438-17443 (1997)
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
Gingras AC, et al.
Genes & Development, 13(11), 1422-1437 (1999)
EIF4EBP1 overexpression is associated with poor survival and disease progression in patients with hepatocellular carcinoma.
Cha YL, et al.
PLoS ONE, 10(2), e0117493-e0117493 (2015)
eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer.
Chao MW, et al.
Oncotarget, 6(27), 24092-24104 (2015)
Hui-Ying Huang et al.
Translational cancer research, 11(5), 1076-1088 (2022-06-17)
New and effective chemotherapy or targeted therapy strategies are needed against laryngeal squamous cell carcinoma (LSCC). We aimed to explore the antitumor effect of dual PI3K/mTOR inhibitor combined with autophagy suppression on LSCC and its underlying mechanism. Hep-2 and AMC-HN-8
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