Skip to Content
Merck
CN

SAB4500433

Anti-Claudin 4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CLD4, CLDN4, CPE- receptor, Claudin-4, Clostridium perfringens enterotoxin receptor

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
5

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 22 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

O14493

UniProt accession no.

O14493

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CLDN4(1364)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

The CLDN4 (claudin 4) gene is mapped to human chromosome 7q11.23. The encoded protein is an integral member, localized to tight junction. It is also expressed in the epithelial basolateral membrane.

Immunogen

The antiserum was produced against synthesized peptide derived from human Claudin 4.

Immunogen Range: 160-209

Biochem/physiol Actions

CLDN4 (claudin 4) is associated with epithelial differentiation, and is widely implicated in carcinomas. Its expression is considered to differentiate carcinoma with that of sarcoma. Claudin 4 expression is implicated in gastric cancer induced by Helicobacter pylori infection. It contributes to invasion, metastasis and prognosis of the disease. The CLDN4 gene is known to be overexpressed in a number of chemoresistant and metastatic cancer. Its localization to the tight junction prevents paracellular diffusion. Along with this, the extracellular loop interaction mediated by claudin 4 with the neighbouring cells makes it a differentiation marker.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
310141

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Claudin-1,-3 and-4 proteins and mRNA expression in benign and malignant breast lesions: a research study
Thokes AM, et al.
Breast Cancer Research, 7(2), R296-R296 (2005)
Claudin-4 expression distinguishes SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas
Schaefer IM, et al.
Modern Pathology, 30(4), 539-539 (2017)
Role of TGF-beta-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer
Rachakonda G, et al.
Cellular Signalling, 28(10), 1537-1544 (2016)
Claudin-4 activity in ovarian tumor cell apoptosis resistance and migration
Hicks DA, et al.
BMC Cancer, 16(1), 788-788 (2016)
TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells
Chavarria-Velazquez CO, et al.
Immunobiology, 223(1), 38-48 (2018)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service